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Matrix Metalloproteinase-14 (MMP-14) fluorometric drug discovery kit

 
BML-AK417-0001 96 wells 496.00 USD
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A QuantiZyme™ Assay System. The MMP-14 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay sytem designed to screen for inhibitors of matrix metalloproteinase-14 (MMP-14, membrane-type matrix metalloproteinase 1, MT1-MMP) using a quenched fluorogenic peptide: OMNIMMP® fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties. The assays are performed in a convenient 96-well microplate format. Also included are active enzyme, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet.
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Product Specification

Alternative Name:Membrane type matrix metalloproteinase 1, MT-1 MMP
 
Applications:Fluorescent detection, HTS
Activity assay
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Kit/Set Contains:MMP-14 enzyme (human) (recombinant), substrate, calibration standard, Assay Buffer, 96-well white microplate.
 
UniProt ID:P45452
 

Product Literature References

The effects of Candida proteinases on human proMMP-9, TIMP-1 and TIMP-2: P. Parnaren, et al.; Mycoses 54, 325 (2011), Abstract;

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Datasheet
MSDS
Certificate of Analysis
Manual

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MMP
MMP-14
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MMP-14 Activity kit
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