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CV-Cathepsin B detection kit

 
BML-AK125-0001 1 Kit 246.00 USD
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Elevated cathepsin enzyme activity often indicates the presence of a pathological condition including cancer, Alzheimer's disease, autoimmune disease, and osteoporosis. Based on the dye cresyl violet and the cathepsin B ArgArg peptide recognition sequence, this kit allows the detection of cathepsin B activity in living cells by fluorescence microscopy. Once cells are grown, staining is completed in just a few minutes. Hoechst 33342 stain and Acridine Orange are also included to allow visualization of nuclei and lysosomes.

Product Specification

Applications:Fluorescence microscopy, Fluorescent detection
 
Application Notes:Cited sample types include mouse microglial cells, human monocytic leukemia cells, and human PBMC.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Kit/Set Contains:CV-(RR)2 reagent, Acridine Orange, Hoechst 33342 stain
 
UniProt ID:P07858
 

Product Literature References

Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia: Z. Wu, et al.; Neurobiol. Aging 34, 2715 (2013), Application(s): Activity detected in mouse microglial cells., Abstract;
Ethanol Inhibits Activation of NLRP3 and AIM2 Inflammasomes in Human Macrophages-A Novel Anti-Inflammatory Action of Alcohol: K. Nurmi, et al.; PLoS One 8, e78537 (2013), Application(s): Activity detected in human monocytic leukemia cells., Abstract; Full Text
Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis: E.J. Rodriguez-Franco, et al.; PLoS One 7, e3657 (2012), Application(s): Activity detected in human PBMC., Abstract; Full Text
Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain: L. Sun, et al.; J. Neurosci. 32, 11330 (2012), Application(s): Activity detected in mouse microglial cells., Abstract; Full Text
Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway: K. Niemi, et al.; J. Immunol. 186, 6119 (2011), Application(s): Activity detected in human monocytic leukemia cells., Abstract; Full Text
Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation: K. Rajamäki, et al.; PLoS One 5, e11765 (2010), Application(s): Activity detected in human monocytic leukemia cells., Abstract; Full Text

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