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Spectinomycin . dihydrochloride

Aminocyclitol antibiotic
 
BML-A280-0010 10 g 116.00 USD
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Replaces Prod. #: ALX-380-278

Aminocyclitol antibiotic active against Gram-negative and Gram-positive bacteria (Gonnococcus only). In clinical use for gonorrhea. Inhibits protein synthesis (elongation) by interfering with peptidyl tRNA translocation. Binds to the 30S subunit of bacterial ribosomes. Mutation in rpsE (the gene for ribosomal protein S5) prevents binding of spectinomycin.

Product Specification

Alternative Name:Spectinomycin . dihydrochloride . pentahydrate, U-18409AE
 
Formula:C14H24N2O7 . 2HCl . 5H2O
 
MW:495.3
 
CAS:22189-32-8
 
MI:14: 8739
 
RTECS:WG7400000
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in water (50mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Use/Stability:Stable for up to 1 year after receipt when stored at +4°C. Stock solutions are stable for up to 3 months at -20°C.
 
Technical Info/Product Notes:Note: Product is not sterile.
 
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Product Literature References

In vivo selection of spectinomycin-binding RNAs: J.M. Zimmerman & L.J. Maher; Nucl. Acids Res. 30, 5425 (2002), Abstract; Full Text
Spectinomycin kinase from Legionella pneumophila. Characterization of substrate specificity and identification of catalytically important residues: P.R. Thompson, et al.; J. Biol. Chem. 273, 14788 (1998), Abstract; Full Text
Isolation of a gene encoding a novel spectinomycin phosphotransferase from Legionella pneumophila: Antimicrob. Agents Chemother.; T.M. Suter, et al. 41, 1385 (1997), Abstract; Full Text
The selection in vivo and characterization of an RNA recognition motif for spectinomycin: G. Thom & C.D. Prescott; Bioorg. Med. Chem. 5, 1081 (1997), Abstract;
Spectinomycin versus tetracycline for the treatment of gonorrhea: W.W. Karney, et al.; N. Engl. J. Med. 296, 889 (1977), Abstract;
New antibiotics: epicillin, minocycline and spectinomycin a summary of their antibacterial activity, pharmacokinetic properties and therapeutic efficacy: R.N. Brogden & G.S. Avery; Drugs 3, 314 (1972), Abstract;
Sensitivity and Resistance to Spectinomycin in Escherichia coli: P. Anderson; J. Bacteriol. 100, 939 (1969), Abstract; Full Text

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