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Lincomycin

Antibiotic
 
BML-A240-0001 1 g 72.00 USD
 
BML-A240-0005 5 g 279.00 USD
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Lincosamide antibiotic. 23S Inhibits bacterial protein synthesis. Active against Gram-positive bacteria. Lincomycin binds to the 50S subunit of bacterial ribosomes and suppresses protein synthesis.

Product Specification

Alternative Name:U-10149A
 
Formula:C18H34N2O6S.HCl.H2O
 
MW:443.0
 
Source:Isolated from Streptomyces lincolnensis
 
CAS:7179-49-9
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in water (50mg/ml)
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at 0-4°C for up to 2 years. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Lincomycin protects mice from septic shock in beta-glucan-indomethacin model: S. Nameda et al.; Biol. Pharm. Bull. 30, 2312 (2007), Abstract;
Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics: W.S. Champney & C.L. Tober; Curr. Microbiol. 41, 126 (2000), Abstract;
Peptidyl transferase antibiotics perturb the relative positioning of the 3'-terminal adenosine of P/P'-site-bound tRNA and 23S rRNA in the ribosome: S.V. Kirillow et al.; Rna 5, 1003 (1999), Abstract;
Slow-onset inhibition of ribosomal peptidyltransferase by lincomycin: S. Kallia-Raftopoulos et al.; Arch. Biochem. Biophys. 298, 332 (1992), Abstract;
Microbial kinetics of drug action against gram-positive and gram-negative organisms. III: Effect of lincomycin and clindamycin combinations on Staphylococcus aureus and Escherichia coli: S.M. Heman-Ackah et al.; J. Pharm. Sci. 64, 1621 (1975), Abstract;
Animal Toxicity Studies of a New Antibiotic, Lincomycin: J. Grey et al.; Toxicol. Appl. Pharmacol. 6, 476 (1964), Abstract;

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