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Cyclosporin A

Immunosuppressant
 
BML-A195-0100 100 mg 59.00 USD
 
BML-A195-0500 500 mg 234.00 USD
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Replaces Prod. #: ALX-380-002

Cyclosporin A (CsA) is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. CsA binds to cyclophilin and suppresses its proline rotamase activity. The CsA-cyclophilin complex inhibits calcineurin, a type 2B phosphatase. It is an important diagnostic tool for the characterization of permeability transition-related phenomena. It inhibits mitochondrial permeability transition pore opening however, pore inhibition becomes less efficient at increasing Ca2+ loads and inhibition is transient. Inhibits staurosporin-induced apoptosis in cultured neural cells and rotenone-induced apoptosis in PC-12 cells. Inhibits cytochrome c release from mitochondria. Inhibits nitric oxide (NO) synthesis.

Product Specification

Alternative Name:CsA
 
Formula:C62H111N11O12
 
MW:1202.6
 
Source:Isolated from Fusarium solani
 
CAS:59865-13-3
 
Purity:≥98% (Assay)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in  DMSO (25mg/ml), methanol, 100% ethanol (25mg/ml), acetone or petroleum ether; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Interactions of human P-glycoprotein transport substrates and inhibitors at the drug binding domain: Functional and molecular docking analyses: O. Kadioglu, et al.; Biochem. Pharmacol. 104, 42 (2016), Application(s): Cell culture, Abstract;
Monocyte Trafficking, Engraftment, and Delivery of Nanoparticles and an Exogenous Gene into the Acutely Inflamed Brain Tissue - Evaluations on Monocyte-Based Delivery System for the Central Nervous System: H.I. Tong, et al.; PLoS One 11, e0154022 (2016), Application(s): Cell culture, Abstract; Full Text
A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial associated necrosis in breast cancer: A. Bastian, et al.; J. Pharmacol. Exp. Ther. 353, 392 (2015), Application(s): Assay, Abstract; Full Text
Effects of embryonic cyclosporine exposures on brain development and behavior: D.E. Clift, et al.; Behav. Brain Res. 282, 117 (2015), Application(s): Cell Culture, Abstract;
Melatonin suppresses cyclosporine A-induced autophagy in rat pituitary GH3 cells: Y.M. Yoo & E.B. Jeung; J. Pineal Res. 48, 204 (2010), Abstract;
Rationale for T cell inhibition by cyclosporin A in major autoimmune diseases: G.F. Ferraccioli, et al.; Ann. N. Y. Acad. Sci. 1051, 658 (2005), Abstract;
New aspects of cyclosporin a mode of action: from gene silencing to gene up-regulation: L. Mascarell & P. Truffa-Bachi; Mini. Rev. Med. Chem. 3, 205 (2003), Abstract;
Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury: A.P. Halestrap, et al.; Mol. Cell. Biochem. 174, 167 (1997), Abstract;
Cyclosporin A, FK506 and rapamycin: more than just immunosuppression: J. Kunz & M.N. Hall; Trends. Biochem. Sci. 18, 334 (1993), Abstract;
FK506 and ciclosporin: molecular probes for studying intracellular signal transduction: J. Liu; Trends. Pharmacol. Sci. 14, 182 (1993), Abstract;
Immunological actions of cyclosporin A in rheumatoid arthritis: D. Yocum; Br. J. Rheumatol. 32 Suppl 1, 38 (1993), Abstract;
Immunosuppression for organ grafting -- observations on cyclosporin A: R.Y. Calne; Immunol. Rev. 46, 113 (1979), Abstract;
Cyclosporin A and C-New metabolites from Trichodermapolysporum : M. Dreyfuss, et al.; Europ. J. Appl. Microbiol. 3, 125 (1976),

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