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Alamethicin

Antibiotic that increases membrane permeability
 
BML-A150-0005 5 mg 115.00 USD
 
BML-A150-0025 25 mg 494.00 USD
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Replaces Prod. #: ALX-380-046

Mixture of alamethicin homologs. Membrane permeabilizing antibiotic. Applications include increasing [32P] incorporation into phosphatidylinositol 4-phosphate and permeabilization of sarcoplasmic reticulum vesicles. Causes fusion of lipid vesicles.

Product Specification

Alternative Name:U-22324
 
Sequence:Ac-2-MeAla-L-Pro-2-MeAla-L-Ala-2-MeAla-L-Ala-L-Gln-2-MeAla-L-Val-2-MeAla-Gly-L-Leu-2-MeAla-L-Pro-L-Val-2-MeAla-2-MeAla-L-Glu-L-Gln-L-phenylalaninol
 
Formula:C92H150N22O25
 
MW:1964.3
 
CAS:27061-78-5
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO, 100% ethanol or methanol.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C.
 
BML-A150 structure
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BML-A150 structure

Product Literature References

Channel-forming activity of alamethicin: effects of covalent tethering: G.A. Woolley; Chem. Biodivers. 4, 1323 (2007), Review, Abstract;
Ligand-induced extramembrane conformation switch controlling alamethicin assembly and the channel current: S. Futaki & K. Asami; Chem. Biodivers. 4, 1313 (2007), Review, Abstract;
Model ion channels: gramicidin and alamethicin: G. A. Woolley & B. A. Wallace; J. Membr. Biol. 129, 109 (1992), Review, Abstract;
Regulation of polyphosphoinositide synthesis in cardiac membranes: E. Quist, et al.; Arch. Biochem. Biophys. 271, 21 (1989), Abstract;
The production of alamethicins by Trichoderma spp: D. Brewer, et al.; Can. J. Microbiol. 33, 619 (1987), Abstract;
Adenylate cyclase in sarcoplasmic reticulum of skeletal muscle: distribution, orientation, and regulation: M. Nakagawa & J.H. Willner; J. Cyclic Nucleotide Protein Phosphor. Res. 11, 237 (1986), Abstract;
The use of ionophores and channel formers in the study of the function of biological membranes: A. Gomez-Puyou & C. Gomez-Lojero; Curr. Top. Bioener. 6, 221 (1977),
Alamethicin-mediated fusion of lecithin vesicles: A.L.Y. Lau and S.I. Chan; PNAS 72, 2170 (1975), Abstract;
The primary structure of alamethicin: J.W. Payne, et al.; Biochem. J. 117, 757 (1970), Abstract;

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