The SCREEN-WELL® Cardiotoxicity Library is a focused collection of 130 compounds with defined and diverse cardiotoxicity, including ion channel blockage, mitochondrial toxicity, arrhythmia, fibrosis, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development.
Product Details
| Applications: | HTS
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| Contents: | 130 compounds with defined and diverse cardiotoxicity. A variety of structurally and mechanistically different compound classes, as well as nontoxic controls, are included. |
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| Quantity: | 100 µl/well or 500 µl/well |
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| Concentration: | DMSO solutions (10mM). |
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| Use/Stability: | Stable for at least one year from the date of receipt when stored at -80°C. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Technical Info/Product Notes: | 
Application Note (Cardiotoxicity Application):
Multi‐Parameter in vitro Assessment of Compound Effects on Cardiomyocyte Physiology Using Induced Pluripotent Stem Cells (iPSC) |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data: L. Ye, et al.; Toxicol. Appl. Pharmacol.
454, 116250 (2022),
Abstract;
Multiparameter Phenotypic Profiling in MCF-7 Cells for Assessing the Toxicity and Estrogenic Activity of Whole Environmental Water: W. Wang, et al.; Environ Sci. Technol.
52, 9277 (2018),
Application(s): Phenotypic Profiling in MCF‑7 Cells,
Abstract;
hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen: A.M. da Rocha, et al.; Sci Rep.
7, 13834 (2017),
Abstract;
Full Text
Assessment of drug-induced arrhythmic risk using limit cycle and autocorrelation analysis of human iPSC-cardiomyocyte contractility: R.J. Kirby, et al.; Toxicol. Appl. Pharmacol.
305, 250 (2016),
Application(s): Cardiomyocyte contractility patterns and autocorrelation to drug-induced beat irregularity with known hERG inhibitors,
Abstract;
Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity: O. Sirenko, et al.; Toxicol. Appl. Pharmacol.
273, 500 (2013),
Abstract;
Multiparameter in vitro assessment of compounds effects on cardiomyocyte physiology using iPSC cells: O. Sirenko, et al.; J. Biomol. Screen.
18, 39 (2013),
Abstract;
