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SCREEN-WELL® Cardiotoxicity library

Essential standards for predictive toxicology screening
 
BML-2850-0500 1 Library 500 µl/well Inquire for pricing
 
BML-2850-0100 1 Library 100 µl/well Inquire for pricing
Do you need bulk/larger quantities?
 
The SCREEN-WELL® Cardiotoxicity Library is a focused collection of 130 compounds with defined and diverse cardiotoxicity, including ion channel blockage, mitochondrial toxicity, arrhythmia, fibrosis, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development.

Product Specification

Applications:HTS
 
Kit/Set Contains:130 compounds with defined and diverse cardiotoxicity. A variety of structurally and mechanistically different compound classes, as well as nontoxic controls, are included.
 
Quantity:100 µl/well or 500 µl/well
 
Concentration:DMSO solutions (10mM).
 
Use/Stability:Stable for at least one year from the date of receipt when stored at -80°C.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Technical Info/Product Notes:

Application Note (Cardiotoxicity Application):
Multi‐Parameter in vitro Assessment of Compound Effects on Cardiomyocyte Physiology Using Induced Pluripotent Stem Cells (iPSC)
 

Product Literature References

Assessment of drug-induced arrhythmic risk using limit cycle and autocorrelation analysis of human iPSC-cardiomyocyte contractility: R.J. Kirby, et al.; Toxicol. Appl. Pharmacol. 305, 250 (2016), Application(s): Cardiomyocyte contractility patterns and autocorrelation to drug-induced beat irregularity with known hERG inhibitors, Abstract;
Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity: O. Sirenko, et al.; Toxicol. Appl. Pharmacol. 273, 500 (2013), Abstract;
Multiparameter in vitro assessment of compounds effects on cardiomyocyte physiology using iPSC cells: O. Sirenko, et al.; J. Biomol. Screen. 18, 39 (2013), Abstract;

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