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Screen-Well® Cardiotoxicity library

Essential standards for predictive toxicology screening
 
BML-2850-0500 1 Library 500 µl/well INQUIRE
 
BML-2850-0100 1 Library 100 µl/well INQUIRE
 
The Screen-Well™ Cardiotoxicity Library is a focused collection of 130 compounds with defined and diverse cardiotoxicity, including ion channel blockage, mitochondrial toxicity, arrhythmia, fibrosis, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development.

Product Specification

Applications:HTS
 
Quantity:100 µl/well or 500 µl/well
 
Concentration:DMSO solutions (10mM).
 
Use/Stability:Stable for at least 6 months after receipt when stored at -80°C.
 
Handling:Avoid freeze/thaw cycles.
 
Long Term Storage:-80°C
 
Kit/Set Contains:130 compounds with defined and diverse cardiotoxicity. A variety of structurally and mechanistically different compound classes, as well as nontoxic controls, are included.
 
Background / Technical Information:

Cardiotoxicity Application: Multi‐Parameter in vitro Assessment of Compound Effects on Cardiomyocyte Physiology Using Induced Pluripotent Stem Cells (iPSC)
 

Product Literature References

Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity: O. Sirenko, et al.; Toxicol. Appl. Pharmacol. 273, 500 (2013), Abstract;
Multiparameter in vitro assessment of compounds effects on cardiomyocyte physiology using iPSC cells: O. Sirenko, et al.; J. Biomol. Screen. 18, 39 (2013), Abstract;

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