Replaces Prod. #: BML-2841
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Compounds can be used for diverse drug discovery in the fields of cardiology, neuropsychiatry, immunology, oncology and more!
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Contains more than 100 additional compounds compared to our previous FDA approved library versions
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100% known bioactivity and greatest degree of drug-likeness available
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Recently approved FDA compounds are also included
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We provide detailed information in our comprehensive documentation for each compound
Drug repositioning or repurposing can be an important part of any drug discovery program and has led to several blockbuster drugs (e.g. Viagra and Rogaine). High-content screens, new biomarkers and noninvasive imaging techniques have created new opportunities for pursuing novel indications for approved compounds. Being FDA approved and in use in the clinics, all of the compounds in SCREEN-WELL® FDA v. 2.0 Approved Drug Library have known and well-characterized bioactivity, safety and bioavailability - properties which could dramatically accelerate drug development and optimization. The library also avoids irrelevant compounds found in similar libraries, such as herbicides, insecticides, sunscreen agents, and cytotoxic agents. This set provides one of the richest sources of bioactives and offers the greatest degree of drug-likeness available. Hits from this set will provide a significant head start in any drug optimization program. Many of the compounds included can also be provided as standalone compounds for further testing.
Product Details
| Applications: | HTS
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| Contents: | Over 770 compounds, selected to maximize chemical and pharmacological diversity |
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| Quantity: | 100µl per well |
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| Concentration: | 10 mM* in DMSO**
*Compounds are predominantly at concentration of 10mM unless otherwise stated.
**Compounds are predominantly provided in DMSO. Selected compounds are dissolved in nuclease-free water. |
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| Use/Stability: | Stable for at least one year from the date of receipt when stored at -80°C. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Technical Info/Product Notes: |  |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Auranofin inhibits virulence pathways in Pseudomonas aeruginosa: J.K.H. Yam, et al.; Bioorg. Med. Chem.
79, 117167 (2023),
Abstract;
Engineered cardiac tissue model of restrictive cardiomyopathy for drug discovery: B.Z. Wang, et al.; Cell Rep. Med.
4, 100976 (2023),
Abstract;
GPR55 contributes to neutrophil recruitment and mechanical pain induction after spinal cord compression in mice: T. Ono, et al.; Brain Behav. Immun.
110, 276 (2023),
Abstract;
Screening in serum-derived medium reveals differential response to compounds targeting metabolism: K.L. Abbott, et al.; bioRxiv (2023),
Abstract;
Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation: C.B. Schroeter, et al.; Biol. Chem.
404, 355 (2023),
Abstract;
A screen of FDA-approved drugs with minigenome identified tigecycline as an antiviral targeting nucleoprotein of Crimean-Congo hemorrhagic fever virus: M. Hirano, et al.; Antiviral Res.
200, 105276 (2022),
Abstract;
A topological refactoring design strategy yields highly stable granulopoietic proteins: J. Skokowa, et al.; Nat. Commun.
13, 2948 (2022),
Abstract;
FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy: J. Wang, et al.; Microbiol. Spectr.
10, e0250922 (2022),
Abstract;
High Resolution Crystal Structure and Chemical Screening Reveal Pantothenate Kinase as a New Target for Antifungal Development: S. Gihaz, et al.; Structures
30, 1494 (2022),
Abstract;
High-throughput drug screening allowed identification of entry inhibitors specifically targeting different routes of SARS-CoV-2 Delta and Omicron/BA.1: M. Kuzikov, et al.; Biomed. Pharmacother.
151, 113104 (2022),
Abstract;
Inhibitory Effect of Mitoxantrone on Collagen Synthesis in Dermal Fibroblasts: K. Kim, et al.; Ann. Dermatol.
34, 206 (2022),
Abstract;
Sorafenib induces pigmentation via the regulation of β-catenin signalling pathway in melanoma cells: K. Kim, et al.; Exp. Dermatol.
31, 57 (2022),
Application(s): Screening for pigmentation-modulating drugs.,
Abstract;
Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery: A. Silvestri, et al.; Drug Discov. Today
26, 1369 (2021),
Abstract;
Glioblastoma patient-derived cell-based phenotypic drug screening and identification of possible action mechanisms through proteomic analysis: Y.E. Kim, et al.; STAR Protoc.
2, 100849 (2021),
Abstract;
IL13Rα2 Is Involved in the Progress of Renal Cell Carcinoma through the JAK2/FOXO3 Pathway: M.A. Kang, et al.; J. Pers. Med.
11, 284 (2021),
Abstract;
Full Text
iPSC screening for drug repurposing identifies anti-RNA virus agents modulating host cell susceptibility: K. Imamura, et al.; FEBS Open Bio
10, 2211 (2021),
Abstract;
Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors: W. Chiou, et al.; J. Enzyme Inhib. Med. Chem.
36, 147 (2021),
Abstract;
Screening of FDA-Approved Drug Library Identifies Adefovir Dipivoxil as Highly Potent Inhibitor of T Cell Proliferation: L. Voss, et al.; Front. Immunol.
11, 616570 (2021),
Application(s): Screening for compounds modulating proliferation of primary human T cells isolated from PBMCs,
Abstract;
Full Text
Calcineurin phosphatase activity regulates Varicella-Zoster Virus induced cell-cell fusion: M. Zhou, et al.; PLoS Pathog.
16, e1009022 (2020),
Application(s): Screening on transfected CHO-DSP1 cells,
Abstract;
Full Text
DREAM-in-CDM approach and identification of a new generation of anti-inflammatory drugs targeting mPGES-1: S. Zhou, et al.; Sci. Rep.
10, 10187 (2020),
Abstract;
Full Text
Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity: R. Seki, et al.; PLoS One
15, e0237030 (2020),
Application(s): Screening on iPSC-derived immortalized myeloid cell lines,
Abstract;
Full Text
Discovery of Novel Therapeutics for Muscular Dystrophies using Zebrafish Phenotypic Screens: J.J. Widrick, et al.; J. Neuromuscul. Dis.
6, 271 (2019),
Application(s): Screening on dystrophic zebrafish embryos or larvae,
Abstract;
Full Text
Dopamine receptor D2 activation suppresses the radiosensitizing effect of aripiprazole via activation of AMPK: H. Lee, et al.; FEBS Open Bio
9, 1580 (2019),
Abstract;
Full Text
Drug discovery for psychiatric disorders using high-content single-cell screening of signaling network responses ex vivo: S.G. Lago, et al.; Sci. Adv.
5, eaau9093 (2019),
Abstract;
Full Text
Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase: J. Armistead, et al.; J. Cell Bio.
219, e201905190 (2019),
Application(s): Screening on zebrafish embryos,
Abstract;
Full Text
High-throughput screening discovers antifibrotic properties of haloperidol by hindering myofibroblast activation: M. Rehman, et al.; JCI Insight.
4, 123987 (2019),
Abstract;
Full Text
Combating Multidrug-Resistant Pathogens with Host-Directed Nonantibiotic Therapeutics: J.A. Andersson, et al.; Antimicrob. Agents Chemother.
1, e01943 (2018),
Abstract;
Full Text
High-Throughput Screening of Entamoeba Identifies Compounds Which Target Both Life Cycle Stages and Which Are Effective Against Metronidazole Resistant Parasites: G.M. Ehrenkaufer, et al.; Front. Cell. Infect. Microbiol.
8, 276 (2018),
Abstract;
Full Text
Identification of novel macropinocytosis inhibitors using a rational screen of Food and Drug Administration-approved drugs: H.P. Lin, et al.; Br. J. Pharmacol.
175, 3640 (2018),
Abstract;
Full Text
Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway: S.H. Park, et al.; Oncol. Lett.
15, 9687 (2018),
Abstract;
Full Text
Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway.: S.H. Park, et al.; Oncol. Lett.
6, 9687 (2018),
Abstract;
Full Text
Oxytetracycline have the therapeutic efficiency in CD133+ HCC population through suppression CD133 expression by decreasing of protein stability of CD133: Y. Song, et al.; Sci. Rep.
8, 16100 (2018),
Abstract;
Full Text
A screening strategy for the discovery of drugs that reduce C/EBPβ-LIP translation with potential calorie restriction mimetic properties: M.A. Zaini, et al.; Sci. Rep.
7, 42603 (2017),
Abstract;
Full Text
Antiviral Activity of Itraconazole against Echovirus 30 Infection In Vitro: J.S. Lee, et al.; Osong Public Health Res. Perspect.
5, 318 (2017),
Abstract;
Full Text
Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs.: Y. Wang, et al.; Drug Des. Devel. Ther.
11, 1369 (2017),
Abstract;
Full Text
High-Throughput Patch Clamp Screening in Human α6-Containing Nicotinic Acetylcholine Receptors: L.C. Armstrong, et al.; SLAS Discov.
6, 686 (2017),
Abstract;
Full Text
Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug: Y. Dong, et al.; Oncotarget
8, 111728 (2017),
Abstract;
Full Text
Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma: U.I. Scholl, et al.; J. Clin. Invest.
127, 2739 (2017),
Abstract;
Full Text
Screening and Characterization of Drugs That Protect Corneal Endothelial Cells Against Unfolded Protein Response and Oxidative Stress: E.C. Kim, et al.; Invest. Ophthalmol. Vis. Sci.
58, 892 (2017),
Application(s): Screening of bovine corneal endothelial cells,
Abstract;
Full Text
A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection: N.J. Barrows, et al.; Cell Host Microbe
20, 259 (2016),
Abstract;
Full Text
Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses: F.S. Varghese, et al.; Antiviral Res.
126, 117 (2016),
Application(s): Screening and primary validation,
Abstract;
Electrophysiology-Based Assays to Detect Subtype-Selective Modulation of Human Nicotinic Acetylcholine Receptors: G.E. Kirsch, et al.; Assay Drug Dev. Technol.
14, 333 (2016),
Application(s): Assay ability test of profiling nicotinic receptors for subtype-selective modulatory effects,
Abstract;
Full Text
Identification of FDA-approved drugs that target hepatitis B virus transcription: M.A. van de Klundert, et al.; J. Viral. Hepat.
23, 191 (2016),
Abstract;
Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening: V.R. Pothineni, et al.; Drug Des. Devel. Ther.
10, 1307 (2016),
Application(s): Lyme disease treatment,
Abstract;
Full Text
New role for FDA-approved drugs in combating antibiotic-resistant bacteria: J.A. Andersson, et al.; Antimicrob. Agents Chemother.
60, 3717 (2016),
Abstract;
Potential of l-thyroxine to differentiate osteoblast-like cells via Angiopoietin1: S.H. Park, et al.; Biochem. Biophys. Res. Commun.
478, 1409 (2016),
Application(s): Library screened with adapted ELISA system to identify novel drugs that possibly promote differentiation of osteoblast-like cells by inducing Ang1 expression,
Abstract;
Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons: M.M. Georgiadis, et al.; DNA Repair (Amst.)
41, 32 (2016),
Application(s): Cell culture,
Abstract;
Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model: A. Shim, et al.; Sci. Rep.
6, 23110 (2016),
Application(s): Antiviral activity of ICZ against HRVs detected by in vitro screening,
Abstract;
Full Text
Development and use of assay conditions suited to screening for and profiling of SET-domain-targeted inhibitors of the MLL/SET1 family of lysine methyltransferases: J.J. Ferry, et al.; Assay Drug Dev. Technol.
13, 221 (2015),
Abstract;
Full Text
Fluocinolone acetonide is a potent synergistic factor of TGF-β3-associated chondrogenesis of bone marrow-derived mesenchymal stem cells for articular surface regeneration: E.S. Hara, et al.; J. Bone Miner. Res.
30, 1585 (2015),
Abstract;
Full Text
Identification of trichlormethiazide as a Mdr1a/b gene expression enhancer via a dual secretion-based promoter assay: S. Schulze, et al.; Pharma. Res. Per.
3, e00109 (2015),
Application(s): Cell Culture,
Full Text
Mevalonate pathway regulates cell size homeostasis and proteostasis through autophagy: T.P. Miettinen, et al.; Cell Rep.
13, 2610 (2015),
Application(s): Identification of mechanisms related to cell size control,
Abstract;
3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions: C. Wenzel, et al.; Exp. Cell Res.
323, 131 (2014),
Abstract;
A yeast-based assay identifies drugs that interfere with Epstein-Barr virus immune evasion: C. Voisset, et al.; Dis. Model Mech.
7, 435 (2014),
Abstract;
Full Text
Antifungal Application of Nonantifungal Drugs: M. Stylianou, et al.; Antimicrob. Agents Chemother.
58, 1055 (2014),
Application(s): In vitro susceptibility testing of
C. albicans strain SC5314,
Abstract;
Full Text
Fluoxetine prevents dystrophic changes in a zebrafish model of Duchenne muscular dystrophy
: T.A. Waugh, et al.; Hum. Mol. Genet.
23, 4651 (2014),
Application(s): Drug screening in zebrafish model of Duchenne muscular dystrophy,
Abstract;
Host-Directed Antimicrobial Drugs with Broad-Spectrum Efficacy against Intracellular Bacterial Pathogens: D.M. Czyz, et al.; MBio.
5, e01534 (2014),
Application(s): Screening of FDA-approved drugs for compounds that block the intracellular growth of
C. burnetii in THP-1 cells,
Abstract;
Full Text
Fluorescent dye cocktail for multiplex drug-site mapping on human serum albumin: J.C. Er, et al.; ACS Comb. Sci.
15, 452 (2013),
Abstract;
Miniature short hairpin RNA screens to characterize antiproliferative drugs: S. Kittanakom, et al.; G3 (Bethesda)
3, 1375 (2013),
Application(s): Screening of A549 cells,
Abstract;
Full Text
Systematic evaluation of 640 FDA drugs for their effect on CD4⁺Foxp3⁺ regulatory T cells using a novel cell-based high throughput screening assay: R. Mao, et al.; Biochem. Pharmacol.
85, 1513 (2013),
Abstract;
The toll-like receptor agonist imiquimod is active against prions: N. Oumata, et al.; PLoS One
8, e72112 (2013),
Abstract;
Full Text
Identification of Modulators of Hair Cell Regeneration in the Zebrafish Lateral Line: P. Namdara, et al.; J. Neurosci.
32, 3516 (2012),
Application(s): Chemical screen for modulators of hair cell regeneration using zebrafish lateral line neuromasts as a platform,
Abstract;
Full Text
Systematic identification of synergistic drug pairs targeting HIV: X. Tan, et al.; Nat. Biotechnol.
30, 1125 (2012),
Abstract;
General Literature References
Fish in a dish: drug discovery for hearing habilitation: R. Esterberg, et al.; Drug Discov. Today Dis. Models
10, 10.1016 (2013),
Abstract;
Full Text
A Bioluminogenic HDAC Activity Assay: Validation and Screening: F. Halley et al.; J. Biomol. Screen.
16, 1227 (2011),
Abstract;
Cell line and drug-dependent effect of ERBB3 on cancer cell proliferation, chemosensitivity, and multidrug actions: B. Chen et al.; Int. J. High Throughput Screen.
1, 49 (2010), Application,
Full Text
