The SCREEN-WELL® Wnt Pathway library v 2.0 is a focused collection of 71 compounds with defined and diverse Wnt pathway activity, including activators and inhibitors of Wnts, Dishevelled, GSK-3β and other Wnt pathway kinases, TCF/β-catenin, DKK, LRP, Axin, Porcupine, and more. Compounds are dissolved in DMSO at 10mM or 1mM and aliquoted into deep-well plates at 100 or 500µl per well. A variety of structurally and mechanistically different compound classes are included. A useful tool for studying the roles of pro- and anti-Wnt pathway molecules in cells as well as for use in in vitro applications.
Product Details
| Applications: | HTS
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| Contents: | 71 compounds with defined and diverse Wnt pathway activity. A variety of structurally and mechanistically different compound classes are included. |
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| Quantity: | 100 µl/well or 500 µl/well |
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| Concentration: | DMSO solutions (10mM) except for Bafilomycin A which is provided at 1mM in DMSO. |
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| Use/Stability: | Stable for at least one year from the date of receipt when stored at -80°C. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Technical Info/Product Notes: |  |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
TFAP2 transcription factors are regulators of lipid droplet biogenesis: C.C. Scott, et al.; Elife
7, e36330 (2018),
Abstract;
Full Text
ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect: H. Zinecker, et al.; Oncotarget.
8, 106764 (2017),
Abstract;
Full Text
Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma: V.K. Emruli, et al.; BMC Cancer
16, 493 (2016),
Application(s): Cell viability measurements,
Abstract;
Full Text
Identification of novel osteogenic compounds by an ex-vivo sp7:luciferase zebrafish scale assay: E. de Vrieze, et al.; Bone
74C, 106 (2015),
Abstract;
An inverse small molecule screen to design a chemically defined medium supporting long-term growth of Drosophila cell lines: M. Burnette, et al.; Mol. Biosyst.
10, 2713 (2014),
Abstract;
Full Text
Trichostatin A effectively induces apoptosis in chronic lymphocytic leukemia cells via inhibition of Wnt signaling and histone deacetylation: L. Peiffer, et al.; J. Cancer Res. Clin. Oncol.
140, 1283 (2014),
Abstract;
