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SCREEN-WELL® Epigenetics library

 
BML-2836-0500 1 Library 500 µl/well Inquire for pricing
 
BML-2836-0100 1 Library 100 µl/well Inquire for pricing
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The SCREEN-WELL® Epigenetics library contains 43 compounds with defined activity against enzymes which carry out epigenetic modification of lysine. It also includes DNA methylation inhibitors. Compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates at 100 or 500µl per well. The library is a useful tool for chemical genomics, assay development and other pharmacological applications. The library contains inhibitors of these important enzymes: HDACs, SIRTs, Lysine demethylases, HATs, Histone methyl transferases, DNA methyltransferases as well as SIRT activators. A variety of structurally and mechanistically different compound classes are included.
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Product Specification

Applications:HTS
 
Application Notes:Useful tool for chemical genomics, assay development, or other pharmacological applications in the study of epigenetic modifications of lysine and DNA methylation.
 
Kit/Set Contains:43 compounds supplied in DMSO at a concentration of 10mM.
 
Use/Stability:Stable for at least one year from the date of receipt when stored at -80°C.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Technical Info/Product Notes:

Application Note: High Throughput Screening Applications.
Application Note: Automated, High Throughput, HTRF®-Based Detection of Histone Methyltransferase and Demethylase Enzyme Activity.
Application Note: An Automated Profi ling Application using a Direct, Cell-Based, Target-Compound Interaction Assay for G9a Histone Methyltransferase and Bromodomain Proteins.
 

Product Literature References

Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system: K. Takayama, et al.; Nucleic Acids Res. 45, 5198 (2017), Abstract;
Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury: S. Martens, et al.; Cell Death Dis. 8, e2904 (2017), Abstract; Full Text
Altered neuronal network and rescue in a human MECP2 duplication model: S. Nageshappa, et al.; Mol. Psychiatry 21, 178 (2016), Application(s): Drug Screening, Abstract;
Human pluripotent stem cell-derived cortical neurons for high throughput medication screening in autism: A proof of concept study in SHANK3 haploinsufficiency syndrome: H. Darville, et al.; EBioMedicine 9, 293 (2016), Application(s): Drug screening, Abstract;
Identification of novel pathways and molecules able to down-regulate PHOX2B gene expression by in vitro drug screening approaches in neuroblastoma cells: E. Di Zanni, et al.; Exp. Cell Res. 336, 43 (2015), Application(s): Drug Screening, Abstract;
A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages: G. Pegoraro, et al.; BMC Microbiol. 14, 98 (2014), Abstract; Full Text
TR-FRET cellular assays for interrogating posttranslational modifications of histone H3: T. Machleidt, et al.; J. Biomol. Screen. 16, 1236 (2011), Abstract; Full Text

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For Research Use Only. Not for use in diagnostic procedures.
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