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SCREEN-WELL® Kinase Inhibitor library

BML-2832-0500 1 Library 500 µl/well Inquire for pricing
BML-2832-0100 1 Library 100 µl/well Inquire for pricing
Do you need bulk/larger quantities?
The SCREEN-WELL® Kinase Inhibitor Library contains 80 known kinase inhibitors of well-defined activity. Inhibitors are supplied dissolved in DMSO at 10 mM and aliquoted into deep-well plates at either 100 or 500 microliters per well. The library is an ideal tool for chemical genomics, assay development and other pharmacological applications. Includes inhibitors of these important kinases: Insulin/IGF Receptors, PI 3-Kinase, CaM Kinase II, JAK, PKA, CDK, JNK, PKC, CKI II, MAPK, RAF, EGFR, MEK, SAPK, GSK, MLCK, Src-family, IKK, PDGFR, VEGFR and many more.

Product Specification

Kit/Set Contains:80 compounds including inhibitors of these important kinases: BTK, CaM Kinase, CDK, CKI & II, EGFR, GSK, IKK, Insulin receptor, JAK, JNK, MAPK, MEK, MLCK, PI 3-Kinase, PDGFR, PKA, PKC, RAF, SAPK, Src-family, VEGFR, and more.
Quantity:100µl or 500µl per well
Formulation:DMSO solutions.
Use/Stability:Stable for at least one year from the date of receipt when stored at -80°C.
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Technical Info/Product Notes:

Product Literature References

Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells: J.H. Rhim, et al.; Sci. Rep. 6, 26547 (2016), Abstract; Full Text
Estradiol modulates myosin regulatory light chain phosphorylation and contractility in skeletal muscle of female mice: S. Lai, et al.; Am. J. Physiol. Endocrinol. Metab. 310, E724 (2016), Abstract;
Human pluripotent stem cell-derived cortical neurons for high throughput medication screening in autism: A proof of concept study in SHANK3 haploinsufficiency syndrome: H. Darville, et al.; EBioMedicine 9, 293 (2016), Application(s): Screening of compounds in humans with autism, Abstract;
Identification of anti-proliferative kinase inhibitors as potential therapeutic agents to treat canine osteosarcoma: U. Mauchle, et al.; Vet. J. 205, 281 (2015), Abstract;
MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish: P.R. Lundegaard, et al.; Chem. Biol. 15, 330 (2015), Application(s): Screening of compounds in Zebrafish, Abstract;
High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines: A. Ketley, et al.; Hum. Mol. Genet. 23, 1551 (2014), Application(s): Screening of fibroblasts, Abstract; Full Text
The mammalian circadian clock protein period counteracts cryptochrome in phosphorylation dynamics of circadian locomotor output cycles kaput (CLOCK): R. Matsumura, et al.; J. Biol. Chem. 289, 32064 (2014), Abstract; Full Text
A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4: S.N. Krishna, et al.; PLoS One 8, e81504 (2013), Abstract; Full Text
Novel MicroRNA Reporter Uncovers Repression of Let-7 by GSK-3β: R. Guo, et al.; PLoS One 8, e66330 (2013), Abstract; Full Text
IκB kinase/nuclear factor κB-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling: M.J. Schmeisser, et al.; J. Neurosci. 32, 5688 (2012), Abstract; Full Text
Protein kinase inhibitors that inhibit induction of lytic program and replication of Epstein-Barr virus: R. Goswami, et al.; Antiviral Res. 96, 296 (2012), Abstract;
Small molecule screening identifies targetable zebrafish pigmentation pathways: S. Colanesi, et al.; Pigment Cell Melanoma Res. 25, 131 (2012), Abstract;
Small-molecule modulators of Listeria monocytogenes biofilm development: U.T. Nguyen, et al.; Appl. Environ. Microbiol. 78, 1454 (2012), Abstract; Full Text
A small molecule discrimination map of the antibiotic resistance kinome: T. Shakya, et al.; Chem. Biol. 18, 1591 (2011), Abstract;
Tumor suppression by RNA from C/EBPβ 3′ UTR through the inhibition of protein kinase Cε activity: Y. Wang, et al.; PLoS One 6, e16543 (2011), Abstract; Full Text
Amphotericin B, identified from a natural product screen, antagonizes CNS inhibitors to promote axon growth via activation of an Akt pathway in neurons: Y. Gao et al.; J. Neurochem. 113, 1331 (2010), Abstract;
Cell treatment and lysis in 96-well filter-bottom plates for screening Bcr-Abl activity and inhibition in whole-cell extracts: M.R. Mand et al.; J. Biomol. Screen. 15, 434 (2010), Abstract;
High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation: K.J. Leuchowius et al.; Mol. Cell. Proteomics 9, 178 (2010), Abstract;
A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation: J. P. Saxe; Chem. Biol. 14, 1019 (2007), Abstract;
High-content classification of nucleocytoplasmic import or export inhibitors: Y.-J. Kwon et al.; J. Biomol. Screen. 12, 621 (2007), Abstract;
A robust screen for inhibitors and enhancers of phosphoinositide-3 kinase (PI3K) activities by ratiometric fluorescence superquenching: C. Stankewicz et al.; J. Biomol. Screen . 11, 413 (2006), Abstract;
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition: J. Trapp et al.; J. Med. Chem. 49, 7307 (2006), Abstract;
Biotinylated peptides for rapid identification of substrates and inhibitors of kinases and phosphatases with fluorescence superquenching : S. Wittenburg, et al.; Assay Drug Dev. Technol. 4, 535 (2006), Abstract;
Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling: P. O. Krutzik; Nat. Methods. 3, 361 (2006), Abstract;
State-based discovery: a multidimensional screen for small-molecule modulators of EGF signaling: M. Sevecka et al.; Nat. Methods. 3, 825 (2006), Abstract;

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