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SCREEN-WELL® Orphan ligand library

 
BML-2825-0500 1 Library 500 µl/well Inquire for pricing
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The SCREEN-WELL® Orphan ligand library contains 84 compounds with defined, putative, potential or speculative biological activity but whose protein binding partners have not been identified. Ligands are supplied dissolved in biocompatible solvents at 10mM and aliquoted into a deep-well plate at 500µl per well. The library is a rich source of ligands for receptor de-orphaning. Includes the following classes of ligands: Trace Amines, Neurotransmitter Metabolites, Endogenous β-carbolines, Urinary Metabolites, Nicotine Congeners, D-Amino Acids. Receptors for endogenous trace amines have been deorphanized. Endogenous β-carbolines have been shown to display varied biological effects such as hallucinations, hypotension and others. Nicotine congeners such as nornicotine are biologically active and may act at novel nicotinic receptor subtypes.

Product Specification

Applications:HTS
 
Quantity:84 compounds, 500μl per compound
 
Use/Stability:Stable for at least one year from the date of receipt when stored at -80°C.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
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Product Literature References

A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators: P. Stoilov, et al.; PNAS 105, 11218 (2008), Abstract;
A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation: J. P. Saxe; Chem. Biol. 14, 1019 (2007), Abstract;

General Literature References

Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay: H. Yin, et al.; J. Biol. Chem. 284, 12328 (2009), Abstract;

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