The SCREEN-WELL® neurotransmitter library contains 661 CNS receptor ligands in a 96-well format. Ideal for screening or identifying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays, and for routine pharmacological applications. Includes 13 classes of receptor ligands in 10 deep-well plates:
Adrenergics
Histaminergics(Melatonin Ligands)
Dopaminergics
Ionotropic Glutamatergics
Serotonergics
Metabotropic Glutamatergics
Opioids(Sigma ligands)
GABAergics
Cholinergics
Purinergics (Adenosines)
Each ligand is supplied in solution in a biocompatible solvent at a standard concentration of 10mM (Opioid peptides are supplied at a concentrations of 1mM). Plates are available as a complete set, or individually. Supporting data are included.
Stable for at least one year from the date of receipt when stored at -80°C.
Handling:
Avoid freeze/thaw cycles.
Shipping:
Dry Ice
Long Term Storage:
-80°C
Technical Info/Product Notes:
Regulatory Status:
RUO - Research Use Only
Product Literature References
Screening inducers of neuronal BDNF gene transcription using primary cortical cell cultures from BDNF-luciferase transgenic mice: M. Fukuchi, et al.; Sci. Rep. 9, 11833 (2019), Abstract; Full Text
High-throughput screening for selective appetite modulators: A multibehavioral and translational drug discovery strategy: J. Jordi, et al.; Sci. Adv. 4, eaav1966 (2018), Abstract; Full Text
Identification of TAAR5 Agonist Activity of Alpha-NETA and Its Effect on Mismatch Negativity Amplitude in Awake Rats: A.A. Aleksandrov, et al.; Neurotox. Res. 34, 442 (2018), Application(s): Screening for cAMP activity by bioluminescence resonance energy transfer in HEK293T cell culture, Abstract;
Development and validation of a high-throughput calcium mobilization assay for the orphan receptor GPR88: A.M. Decker, et al.; J. Biomed. Sci. 24, 23 (2017), Abstract; Full Text
A KNIME-based analysis of the zebrafish photomotor response clusters the phenotypes of 14 classes of neuroactive molecules: D. Copmans, et al.; J. Biomol. Screen. 21, 427 (2016), Abstract;
Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes: S.Y. Shaw et al.; Proc. Natl. Acad. Sci. USA 108, 492 (2011), Abstract;