The SCREEN-WELL® Fatty Acid Library contains 64 fatty acids of varying saturation and chain length. Many free fatty acids and their metabolites serve as precursors to important signaling systems (e.g. prostaglandins), act directly as receptor ligands or enzyme inhibitors, and have pro- or anti-atherosclerotic and anti-hypertensive properties through mechanisms that are still being characterized. Therefore, a diverse set of fatty acids can be a rich source of compounds for receptor de-orphaning, inhibitor screening, and high content screening. Fatty acids are supplied dissolved in DMSO at 10 mM and aliquoted into deep-well plates at either 100 or 500 µl per well. This set contains both fatty acids with defined activities and fatty acids with putative biological activities.Library includes: Unsaturated & saturated fatty acids, Arachidonic acid, C10-24 chain length Linolenic acid, E and Z isomers, γ-Linolenic acid and many more.
Product Details
| Applications: | HTS
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| Concentration: | 10mM in DMSO |
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| Use/Stability: | Stable for at least one year from the date of receipt when stored at -80°C. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Technical Info/Product Notes: |  |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Undecanoic acid, lauric acid, and N-tridecanoic acid inhibit Escherichia coli persistence and biofilm formation: X. Jin, et al.; J. Microbiol. Biotechnol.
31, 130 (2021),
Abstract;
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Mechanism of activation for the sirtuin 6 protein deacylase: M.A. Klein, et al.; J. Biol. Chem.
295, 1385 (2020),
Abstract;
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Brown Adipogenic Reprogramming Induced by a Small Molecule: B. Nie, et al.; Cell Rep.
18, 624 (2017),
Abstract;
Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug: Y. Dong, et al.; Oncotarget
8, 111728 (2017),
Abstract;
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Inhibition of indoleamine 2, 3-dioxygenase activity by fatty acids and prostaglandins: A structure function analysis: M. Costabile, et al.; Prostaglandins Leukot. Essent. Fatty Acids
122, 7 (2017),
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Therapeutic strategy for targeting aggressive malignant gliomas by disrupting their energy balance: A.M. Hegazy, et al.; J. Biol. Chem.
291, 21496 (2016),
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Essential role of acyl-ACP synthetase in acclimation of the cyanobacterium Synechococcus elongatus strain PCC 7942 to high-light conditions: N. Takatani, et al.; Plant Cell. Physiol.
56, 1608 (2015),
Abstract;
Human mincle binds to cholesterol crystals and triggers innate immune responses: R. Kiyotake, et al.; J. Biol. Chem.
290, 25322 (2015),
Abstract;
Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin: P. Sukumar, et al.; Circ. Res.
111, 191 (2012),
Abstract;
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Modulation of lipid-induced ER stress by fatty acid shape: J. Deguil, et al.; Traffic
12, 349 (2011),
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