CTRP7 soluble detection set



APO-54N-023-KI01	5x96 wells	550.00 USD

Product Specification

Alternative Name:	Complement C1q Tumor Necrosis Factor-related protein 7, C1qTNF7

Sensitivity:	0.1ng/ml (range 0 to 10ng/ml).

Kit/Set Contains:	1 vial Standard (lyophilized) (STD). 1 vial Coating Antibody (COAT). 1 vial Detection Antibody (DET).

Application:	For the quantitative determination of human and mouse soluble CTRP7 from biological fluids (serum and cell culture supernatant).

Short Term Storage:	+4°C

Handling:	Avoid freeze/thaw cycles. For long term storage keep the standard (STD) at -20°C.

Miscellaneous/General:	Adipose tissue functions as storage of energy and plays a role in monitoring and controlling whole-body metabolism by secreting a number of proinflammatory adipokines, (such as leptin, resistin, tumor necrosis factor-α and interleukin-6), as well as one anti-inflammatory adipokine, adiponectin. Adiponectin is involved in controlling the whole-body metabolism, particularly by increasing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle [1]. A highly conserved family of adiponectin paralogs designated as C1q/Tumor Necrosis Factor-α-Related Proteins (CTRPs) 1-7 has been described in mouse and human [2-5]. This family of proteins exhibits similar structural and biological properties to adiponectin. The CTRPs, unlike adiponectin whose expression is restricted to adipose tissue, are widely expressed by many different adult tissues. Like adiponectin, CTRP2 rapidly induces acetyl-CoA carboxylase, and mitogen-activated protein kinase phosphorylation in C2C12 myotubes, which resulted in increased glycogen accumulation and fatty acid oxidation, and CTRP7 (as well as CTRPs 1, 2 and 3) induces AMP-activated protein kinase phosphorylation. The activity of the CTRPs suggests that some members of the CTRP family of proteins could substitute for adiponectin function in vivo.

Background / Technical Information:	UniProt ID Q8BVD7: CTRP7 (mouse)UniProt ID Q9BXJ2: CTRP7 (human)

General Literature References

C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen: G. Lasser, et al.; Blood 107, 423 (2006), Abstract;

Cartducin, a paralog of Acrp30/adiponectin, is induced during chondrogenic differentiation and promotes proliferation of chondrogenic precursors and chondrocytes: T. Maeda, et al.; J. Cell Physiol. 206, 537 (2006), Abstract;

Adipose tissue, adipokines, and inflammation: G. Fantuzzi; J. Allergy Clin. Immunol. 115, 911 (2005), Abstract;

The adiponectin paralog CORS-26 has anti-inflammatory properties and is produced by human monocytic cells: J. Weigert, et al.; FEBS Lett. 579, 5565 (2005), Abstract;

A family of Acrp30/adiponectin structural and functional paralogs: G.W. Wong, et al.; PNAS 101, 10302 (2004), Abstract;