Progranulin (human) ELISA Kit

Sensitive ELISA kit for this key cell signaling molecule for development, wound repair and inflammation.



ALX-850-376-KI01	96 wells	580.00 USD

Replaces Prod. #: AG-45A-0018

Sensitive – use less precious sample per test compared to Western blot
Rapid – reliable results in just 2.5 hours
Quantitative – obtain statistically significant results and compare data between multiple experiments
Simple – efficient and well-established protocols

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Product Specification

Alternative Name:	Proepithelin, PEPI, PC Cell-derived Growth Factor

Sensitivity:	18pg/ml (range 0.075-2500pg/ml)

Assay Time:	2.5 hours

Application:	For the quantitative determination of progranulin in human serum or plasma.

Long Term Storage:	+4°C

Miscellaneous/General:	Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).

UniProt ID:	P28799

General Literature References

Progranulin: normal function and role in neurodegeneration: J. L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008), (Review), Abstract;

Progranulin in frontotemporal lobar degeneration and neuroinflammation: Z. Ahmed, et al.; J. Neuroinflammation 4, 7 (2007), (Review), Abstract; Full Text

Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis: Z. He & A. Bateman; J. Mol. Med. 81, 600 (2003), Abstract;

Progranulin is a mediator of the wound response: Z. He, et al.; Nat. Med. 9, 225 (2003), Abstract;

Granulins, a novel class of peptide from leukocytes: A. Bateman, et al.; BBRC 173, 1161 (1990), Abstract;