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ADMA direct (mouse/rat) ELISA kit

 
ALX-850-327-KI01 96 wells 1,447.00 USD
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The ADMA direct (mouse/rat) ELISA kit is a complete assay for the quantitative determination of ADMA concentration. This kit is to be used with EDTA-plasma, serum, and cell culture supernatants from mouse or rat origins. The ADMA direct (mouse/rat) ELISA has no cross-reactivity with SDMA, NMMA or L-arginine.

Product Specification

Sensitivity:0.05μmol/l
 
Assay Time:15 to 20 hours + 1 hour
 
Applications:ELISA
 
Application Notes:For the quantitative detection of asymmetrical dimethylarginine (ADMA) in mouse or rat EDTA-plasma, serum, and cell culture supernatants. Does not cross-react with SDMA, NMMA or L-arginine.
 
Species reactivity:Mouse, Rat
 
Quantity:96 wells (~80 tests).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Scientific Background:Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis. NO is one of the major endothelium-derived vasoactive mediators and is involved in the modulation of blood flow and blood pressure. Even small changes of ADMA concentration alter vascular NO production, vascular tone, and systemic vascular resistence. Elevated ADMA concentrations are found in patients with diabetes mellitus, hypercholeste-rolemia, hypertension, pulmonary hypertension, peripheral arterial disease, chronic renal failure, preeclampsia or erectile dysfunction. ADMA is therefore a cardiovascular risk factor.
 

Product Literature References

Cardiomyocyte dimethylarginine dimethylaminohydrolase1 attenuates left-ventricular remodeling after acute myocardial infarction: involvement in oxidative stress and apoptosis: L. Hou, et al.; Basic Res. Cardiol. 113, 28 (2018), Application(s): ELISA of mouse plasma, Abstract;
Erythropoietin reduces collagen deposition after myocardial infarction but does not improve cardiac function: F.G. Pessoa, et al.; Can. J. Physiol. Pharmacol. 96, 541 (2018), Application(s): ELISA of rat serum, Abstract;
Cilostazol attenuates intimal hyperplasia in a mouse model of chronic kidney disease: W. Chancharoenthana, et al.; PLoS One 12, e0187872 (2017), Application(s): Mouse serum, Abstract; Full Text
Digenic mutations on SCAP and AGXT2 predispose to premature myocardial infarction: Y. Gao, et al.; Oncotarget 8, 100141 (2017), Application(s): Culture supernatant from HEK293T and E. hy926 cells, Abstract; Full Text
Epigallocatechin-3-gallate ameliorates erectile function in aged rats via regulation of PRMT1/DDAH/ADMA/NOS metabolism pathway: D. Chen, et al.; Asian J. Androl. 19, 291 (2017), Application(s): Levels of the ADMA in rat penile tissue were measured, Abstract; Full Text
High-throughput identification of small molecules that affect human embryonic vascular development: H. Vazão, et al.; PNAS 114, E3022 (2017), Application(s): HUAEC- and ESC-human endothelial cell supernatant, Abstract; Full Text
The role of air pollution in myocardial remodeling: A.M. de Oliveira-Fonoff, et al.; PLoS One 12, e0176084 (2017), Application(s): ELISA of rat serum, Abstract; Full Text
Probucol Improves Erectile Function by Restoring Endothelial Function and Preventing Cavernous Fibrosis in Streptozotocin-Induced Diabetic Rats: K.Q. Zhang, et al.; Urology 91, 241.e9 (2016), Application(s): Levels of ADMA measured in rat penile tissue, Abstract;
Treatment of spontaneously hypertensive rats with rosiglitazone ameliorates cardiovascular pathophysiology via antioxidant mechanisms in the vasculature: M. Potenza, et al.; Am. J. Physiol. Endocrinol. Metab. 297, E685 (2009), Abstract; Full Text

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