ADMA direct (mouse/rat) ELISA kit



ALX-850-327-KI01	96 wells	1'492.00 USD

Product Specification

Quantity:	96 wells (~80 tests).

Sensitivity:	0.05μmol/l

Application:	For the quantitative detection of asymmetrical dimethylarginine (ADMA) in mouse or rat EDTA-plasma and serum. Does not cross-react with SDMA, NMMA or L-arginine.

Long Term Storage:	+4°C

Handling:	Store standard and controls at -20°C. Store rest of the kit at +4°C.

Miscellaneous/General:	Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis. NO is one of the major endothelium-derived vasoactive mediators and is involved in the modulation of blood flow and blood pressure. Even small changes of ADMA concentration alter vascular NO production, vascular tone, and systemic vascular resistence. Elevated ADMA concentrations are found in patients with diabetes mellitus, hypercholeste-rolemia, hypertension, pulmonary hypertension, peripheral arterial disease, chronic renal failure, preeclampsia or erectile dysfunction. ADMA is therefore a cardiovascular risk factor.

Manufacturer:	Manufactured by Immundiagnostik AG.

Product Literature References

Treatment of spontaneously hypertensive rats with rosiglitazone ameliorates cardiovascular pathophysiology via antioxidant mechanisms in the vasculature: M. Potenza, et al.; Am. J. Physiol. Endocrinol. Metab. 297, E685 (2009), Abstract; Full Text