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ADMA direct (mouse/rat) ELISA kit

 
ALX-850-327-KI01 96 wells 1,377.00 USD
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Product Specification

Sensitivity:0.05μmol/l
 
Assay Time:15 to 20 hours + 1 hour
 
Applications:ELISA
 
Application Notes:For the quantitative detection of asymmetrical dimethylarginine (ADMA) in mouse or rat EDTA-plasma and serum. Does not cross-react with SDMA, NMMA or L-arginine.
 
Species reactivity:Mouse, Rat
 
Quantity:96 wells (~80 tests).
 
Handling:Store standard and controls at -20°C. Store rest of the kit at +4°C.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Scientific Background:Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis. NO is one of the major endothelium-derived vasoactive mediators and is involved in the modulation of blood flow and blood pressure. Even small changes of ADMA concentration alter vascular NO production, vascular tone, and systemic vascular resistence. Elevated ADMA concentrations are found in patients with diabetes mellitus, hypercholeste-rolemia, hypertension, pulmonary hypertension, peripheral arterial disease, chronic renal failure, preeclampsia or erectile dysfunction. ADMA is therefore a cardiovascular risk factor.
 

Product Literature References

Epigallocatechin-3-gallate ameliorates erectile function in aged rats via regulation of PRMT1/DDAH/ADMA/NOS metabolism pathway: D. Chen, et al.; Asian J. Androl. 19, 291 (2017), Application(s): Levels of the ADMA in rat penile tissue were measured, Abstract; Full Text
Probucol Improves Erectile Function by Restoring Endothelial Function and Preventing Cavernous Fibrosis in Streptozotocin-Induced Diabetic Rats: K.Q. Zhang, et al.; Urology 91, 241.e9 (2016), Application(s): Levels of ADMA measured in rat penile tissue, Abstract;
Treatment of spontaneously hypertensive rats with rosiglitazone ameliorates cardiovascular pathophysiology via antioxidant mechanisms in the vasculature: M. Potenza, et al.; Am. J. Physiol. Endocrinol. Metab. 297, E685 (2009), Abstract; Full Text

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