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Osteoprotegerin (human) ELISA kit

ALX-850-280A-KI01 96 wells 1,308.00 USD
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Replaces Prod. #: ALX-850-280

The Osteoprotegerin (human) ELISA kit is a complete, colorimetric, immunometric immunoassay kit for the quantitative determination of osteoprotegerin in plasma and serum with results in just ~5 hours.

Product Specification

Alternative Name:OPG, TNFRSF 11B, Tumor Necrosis Factor receptor superfamily member 11B, Osteoclastogenesis Inhibitory Factor, OCIF
Sensitivity:1.4pg/ml (range 0 to 500pg/ml)
Assay Time:~5 hours
Applications:ELISA, Colorimetric detection
Application Notes:For the quantitative determination of human osteoprotegerin in serum and plasma.
Species reactivity:Human
Quantity:96 wells (~80 tests).
Shipping:Blue Ice Not Frozen
Long Term Storage:+4°C
Contents:Plate pre-coated with capture antibody, Wash buffer, Detection antibody, Standards, Control, Assay buffer, Conjugate Streptavidin-HRP, TMB solution, Stop solution
Scientific Background:Osteoprotegerin (OPG) or osteoclast inhibitory factor (OCIF) is a glycoprotein of the TNF receptor superfamily 11b (gene name TNFRSF11B). OPG is synthesized as a monomer of 380 amino acids and is assembled as a homodimer within the cell, and then secreted mainly as a disulfide-linked homodimer into the extracellular compartment. OPG is produced by many different tissues and cell types including osteoblasts. OPG is a negative regulator of bone resorption by acting as decoy receptor for RANKL, thus neutralizing its function in osteoclastogenesis. This glycoprotein is also involved in the regulation of vascular calcification.
UniProt ID:O00300

Product Literature References

Activation of the p53 pathway down-regulates the osteoprotegerin (OPG) expression and release by vascular endothelial cells: P. Secchiero, et al.; Blood 111, 1287 (2008), Abstract;
Osteoprotegerin increases leukocyte adhesion to endothelial cells both in vitro and in vivo: G. Zauli, et al.; Blood 110, 536 (2007), Abstract;
An increased osteoprotegerin serum release characterizes the early onset of diabetes mellitus and may contribute to endothelial cell dysfunction: P. Secchiero, et al.; Am. J. Pathol. 169, 2236 (2006), Abstract; Full Text

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