pan-CEACAM (1,5,6,8) (human), mAb (TET2)

ALX-805-081

Revised 01-Feb-10

pan-CEACAM (1,5,6,8) (human), mAb (TET2)
SYNONYMS	BGP, CEA, NCA and CGM6 CD66a/CD66b/CD66c/CD66e
PRODUCT LINE	Cytoskeleton
PRODUCT CATEGORY	CEACAM [CD66] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-805-081-C100		100 µg	450.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	TET2
ISOTYPE:	Mouse IgG2b
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In PBS, pH 7.2, containing 0.01% sodium azide.
IMMUNOGEN:	CEACAM5 (CEA) partially purified from a perchloric acid extract from liver metastases of colonic tumors.
SPECIFICITY:	Recognizes human CEACAM1, 5, 6 and 8.
APPLICATION:	ELISA Flow Cytometry Immunohistochemistry (frozen sections) Western Blot. Optimal conditions must be determined individually for each application.
QUALITY CONTROL:	Routinely tested by flow cytometry on BOSC23 cells transiently transfected with a CEACAM5 expression vector.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.

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Product Specific Literature References

Two CEA and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns: F. Grunert, et al.; Int. J. Cancer 36, 357 (1985) Abstract
CD66 family Workshop: Binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules: F. Grunert, et al.; Leukocyte Typing VI: White cell Differentiation Antigens (T. Kishimoto, et al., eds.), Garland Publishing Inc., New York 1012 (1996)
Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site: S.M. Watt, et al.; Blood 98, 1469 (2001) Abstract; Full Text

General Information

CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM1, CEACAM3-CEACAM8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leukocytes. Overexpression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocytes and dendritic cell activation, receptors of Neisseria species and other bacteria.

General Literature References

Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abstract
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues: S. Hammarström; Semin. Cancer Biol. 9, 67 (1999), (Review) Abstract
Carcinoembryonic antigen: W. Zimmermann; Wiley Encylopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York 459 (2002)

Further Categories Containing This Product:

CD Antibodies • Monoclonal Antibodies