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CD18 (human) monoclonal antibody (MEM-148)

 
ALX-805-043-C100 100 µg 226.00 USD
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Product Specification

Alternative Name:β2 integrin
 
Clone:MEM-148
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Human peripheral blood mononuclear cells.
 
UniProt ID:P05107
 
Species reactivity:Human
 
Specificity:Recognizes free CD18 (β2 integrin) not associated with CD11.
 
Crossreactivity:Does not cross-react with pig CD18.
 
Applications:Flow Cytometry, IP, WB, FUNC
 
Recommended Dilutions/Conditions:Western Blot (non-reducing)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Functional Application: induces homotypic cell aggregation and high-affinity LFA-1 conformation in resting leukocytes.
 
Purity Detail:Protein A-affinity purified.
 
Formulation:Liquid. In PBS, pH 7.4, containing 15 mM sodium azide.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 

Product Literature References

A novel anti-CD18 mAb recognizes an activation-related epitope and induces a high-affinity conformation in leukocyte integrins: K. Drbal, et al.; Immunobiology 203, 687 (2001), Abstract;
A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells: K. Drbal, et al.; Blood 98, 1561 (2001), Abstract; Full Text
Human leukocytes contain a large pool of free forms of CD18: K. Drbal, et al.; BBRC 275, 295 (2000), Abstract;

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