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Fas (human) monoclonal antibody (APO-1-3)

ALX-805-020-C100 100 µg Purified 348.00 USD
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Product Specification

Alternative Name:CD95, APO-1, TNFRSF 6
Immunogen:Human recombinant Fas (CD95; APO-1).
UniProt ID:P25445
Species reactivity:Human
Applications:Flow Cytometry, IP, WB, FUNC
Recommended Dilutions/Conditions:Flow Cytometry (suitable as a primary antibody)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Functional Application: induces apoptosis with or without cross-linking (Protein A), depending on cell type.
Formulation:Liquid. In PBS. Contains no preservatives.
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C

Product Literature References

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes: O. Komine, et al.; Cell Death Differ. (2018), Abstract; Full Text
STAT3 inhibition reduces toxicity of oncolytic VSV and provides a potentially synergistic combination therapy for hepatocellular carcinoma: S. Marozin, et al.; Cancer Gene Ther. 22, 317 (2015), Application(s): Western Blot, Abstract;
Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia: P. Chu, et al.; PNAS 99, 3854 (2002), Abstract; Full Text
Apoptosis and the maintenance of homoeostasis in the immune system: B.A. Osborne; Curr. Opin. Immunol. 8, 245 (1996), Abstract;
Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells: C. Friesen, et al.; Nat. Med. 2, 574 (1996), Abstract;
Autocrine T-cell suicide mediated by APO-1/(Fas/CD95): J. Dhein, et al.; Nature 373, 438 (1995), Abstract;
CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway: E.J. Schattner, et al.; J. Exp. Med. 182, 1557 (1995), Abstract;
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor: F.C. Kischkel, et al.; EMBO J. 14, 5579 (1995), Abstract;
Resistance to APO-1 (CD95) induced apoptosis in T-ALL is determined by a BCL-2 independent anti-apoptotic program: K.M. Debatin & P.H. Krammer; Leukemia 9, 815 (1995), Abstract;
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120: M.O. Westendorp, et al.; Nature 375, 497 (1995), Abstract;
The medical significance of physiological cell death: G. Häcker & D.L. Vaux; Med. Res. Rev. 15, 299 (1995), Abstract;
Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells: P.T. Daniel & P.H. Krammer; J. Immunol. 152, 5624 (1994), Abstract;
APO-1 (CD95) mediated apoptosis in human T-ALL engrafted in SCID mice: K.M. Lücking-Famira, et al.; Leukemia 8, 1825 (1994), Abstract;
Apoptotic cell death induced by a mouse-human anti-APO-1 chimeric antibody leads to tumor regression: L.R. Coney, et al.; Int. J. Cancer 58, 562 (1994), Abstract;
Cell nucleus and DNA fragmentation are not required for apoptosis: K. Schulze-Osthoff, et al.; J. Cell Biol. 127, 15 (1994), Abstract;
Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death: K. Schulze-Osthoff, et al.; EMBO J. 13, 4587 (1994), Abstract;
Inhibition of apoptosis in T cells expressing human T cell leukemia virus type I Tax: K.F. Copeland, et al.; AIDS Res. Hum. Retroviruses 10, 1259 (1994), Abstract;
The apoptosis-1/Fas protein in human systemic lupus erythematosus: E. Mysler, et al.; J. Clin. Invest. 93, 1029 (1994), Abstract;
APO-1-induced apoptosis of leukemia cells from patients with adult T-cell leukemia: K.M. Debatin, et al.; Blood 81, 2972 (1993), Abstract;
Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens: J. Dhein, et al.; J. Immunol. 149, 3166 (1992), Abstract;
Monoclonal-antibody-mediated apoptosis in adult T-cell leukaemia: K.M. Debatin, et al.; Lancet 335, 497 (1990), Abstract;
Monoclonal antibody-mediated tumor regression by induction of apoptosis: B.C. Trauth, et al.; Science 245, 301 (1989), Abstract;

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