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FLIP (human) monoclonal antibody (7F10)

ALX-804-961-0100 100 µg 422.00 USD
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Product Specification

Alternative Name:CASPER, CLARP, I-FLICE, Usurpin, CFLAR
Immunogen:Recombinant human FLIP.
UniProt ID:O15519
Species reactivity:Human
Applications:ELISA, Flow Cytometry, IHC, WB
Recommended Dilutions/Conditions:Western Blot (1:500)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Protein G-affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with the adapter protein, FADD, and caspase-8 and –10, and potently inhibits apoptosis induced by death receptors CD95, DR3, TRAIL-R and TNFR1.
ALX-804-961 WB1
Western blot analysis of FLIP (human), mAb (7F10) (Prod. No. ALX-804-961): Lane 1: MW marker, Lane 2&4: HeLa cell lysate, Lane 3&5: Jurkat cell lysate. The two membranes were blotted with 7F10 or NF6 clones at 2µg/ml separately. The result showed they detected very similar pattern in these cell lysates.
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ALX-804-961 WB1

Product Literature References

Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP: L. Piggott, et al.; Clin. Cancer Res. 24, 2452 (2018), Abstract;
TRAIL-Induced Apoptosis in TRAIL-Resistant Breast Carcinoma Through Quercetin Cotreatment: J.M. Manouchehri, et al.; Breast Cancer (Auckl.) 12, 1178223417749855 (2018), Application(s): Western blot, Abstract; Full Text
Role of p63 and p73 isoforms on the cell death in patients with hepatocellular carcinoma submitted to orthotopic liver transplantation: R. Gonzalez, et al.; PLoS One 12, e0174326 (2017), Abstract; Full Text
Quercetin sensitizes pancreatic cancer cells to TRAIL-induced apoptosis through JNK-mediated cFLIP turnover: J.H. Kim, et al.; Int. J. Biochem. Cell Biol. 78, 327 (2016), Application(s): Western blot; cell lysates, Abstract;
6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression: M.A. Han, et al.; Chem. Biol. Interact. 228, 69 (2015), Abstract;
FAS-ligand regulates differential activation-induced cell death of human T-helper 1 and 17 cells in healthy donors and multiple sclerosis patients: M.T. Cencioni, et al.; Cell. Death Dis. 6, e1741 (2015), Application(s): Western Blot, Abstract; Full Text
G2/M Arrest Sensitises Erythroid Leukemia Cells to TRAIL-induced Apoptosis: S. Cruet-Hennequart, et al.; J. Leuk. 3, 174 (2015), Application(s): Western Blot, Full Text
Helicobacter pylori sensitizes TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human gastric epithelial cells through regulation of FLIP: W.C. Lin, et al.; Cell Death Dis. 5, e1109 (2014), Application(s): Western blot using human gastric adenocarcinoma cell line AGS, Abstract; Full Text

General Literature References

Cellular FLIP is expressed in cardiomyocytes and down-regulated in TUNEL-positive grafted cardiac tissues: T. Imanishi, et al.; Cardiovasc. Res. 48, 101 (2000), Abstract; Full Text

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