Product Details
| Alternative Name: | RIG-1, Retinoic acid-inducible gene 1 protein, DEAD-box protein 58, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 M, Probable ATP-dependent RNA helicase DDX58 |
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| Clone: | SS1A |
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| Host: | Rat |
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| Isotype: | IgG2a |
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| Immunogen: | Synthetic peptide corresponding to C-terminal mouse RIG-I conjugated to KLH. |
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| UniProt ID: | Q6Q899 |
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| Gene/Protein Identifier: | 109906 (Entrez GeneID) |
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| Species reactivity: | Mouse
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| Applications: | WB
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| Purity Detail: | Affinity purified. |
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| Formulation: | Liquid. In PBS, pH 7.2, containing 0.09% sodium azide. |
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| Shipping: | Blue Ice Not Frozen |
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| Long Term Storage: | +4°C |
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| Scientific Background: | RIG-1/DDX58 (Retinoic acid-inducible gene 1 protein/ DEAD-box protein 58) is an RNA helicase that belongs to the DEAD/H box. Contains 2 CARD domains, a helicase ATP-binding domain and a helicase C-terminal domain. Predicted molecular weight approximately 107 kDa. RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses. RIG-1 and MDA5 (melanoma differentiation-associated gene 5) are key intracellular receptors that sense intracellular viral infection and trigger a signal for innate antiviral responses including the production of typeI IFN. Clone SS1A has been shown to be useful for Western blotting of the mouse RIG-1 protein. Involved in innate immune defense against viruses. RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses. |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of RIG-I (mouse), mAb (SS1A) (Prod. No. ALX-804-960) using NIH-3T3 cells extracts (lane 1) and mouse splenocytes (lane 2).
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Product Literature References
The Essential Role of Double-Stranded RNA-Dependent Antivira Signaling in the Degradation of Nonself Single-Stranded RNA in Nonimmune Cells: S. Kimura, et al.; J. Immunol.
201, 1044 (2018),
Abstract;
Influenza A viruses suppress cyclooxygenase-2 expression by affecting its mRNA stability: S.E. Dudek, et al. ; Sci. Rep.
6, 27275 (2016),
Application(s): Western blot,
Abstract;
Full Text
Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity: C.S. Ilkow, et al.; Nat. Med.
21, 530 (2015),
Application(s): Indirect immunofluorescence microscopy, Immunohistochemistry,
Abstract;
