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TRAIL (human) monoclonal antibody (RIK-2)

 
ALX-804-907-0100 100 µg 205.00 USD
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Product Specification

Alternative Name:Apo-2L, TNFSF 10, CD253
 
Clone:RIK-2
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Human TRAIL transfected mouse cell line.
 
UniProt ID:P50591
 
GenBank ID:U57059
 
Gene/Protein Identifier:8743 (Entrez GeneID)
 
Species reactivity:Human
 
Applications:Flow Cytometry
 
Purity Detail:Affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Induces apoptosis in tumorigenic and transformed cell lines, involved in T cell mediated cytotoxicity, TRAIL ligand of cognate receptors induces NF-kappa-B signaling in a variety of cell types. TRAIL is a 30kDa protein known as TNF-related apoptosis inducing ligand, CD253, TNFSF10, or Apo-2L. It can be expressed as a cell surface (30kDa) and soluble ligand (19-20kDa) produced by megakaryocytes and platelets, monocytes, neutrophils, NK cells and activated T cells. This antigen is also expressed on tumor cells and transformed cell lines. TRAIL has been reported to induce apoptosis in tumor and transformed cell lines by a caspase-dependent process. This antibody is useful for flow cytometric staining and blocking studies.
 

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