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MDA5 monoclonal antibody (1B6) (biotin conjugate)

 
ALX-804-878B-C100 100 µg 310.00 USD
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Product Specification

Alternative Name:Helicard, Melanoma differentiation-associated gene 5, Interferon-induced helicase C domain-containing protein 1, RH116, CADM-140 autoantigen, RIG-I-like receptor 2, RLR-2
 
Clone:1B6
 
Host:Mouse
 
Isotype:IgG
 
Immunogen:Recombinant human MDA5 (melanoma differentiation-associated gene 5) (aa 78-555).
 
UniProt ID:Q9BYX4
 
Species reactivity:Human, Mouse
 
Applications:ELISA, WB
 
Recommended Dilutions/Conditions:ELISA (1:10,000)
Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~50kDa by Western blot.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background: MDA5 is a highly conserved helicase whose ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. The helicase domain, once freed from the CARD domains, then translocates from the cytoplasm to the nucleus where it acts on chromatin architecture. This could allow a more easy access of CAD, thereby accelerating the degradation of genomic DNA.
 
804-878B SDS-PAGE
SDS-PAGE Analysis of the MDA5, mAb (1B6) (biotin conjugate). Lane 1. Molecular Weight Marker; Lane 2. MDA5, mAb (1B6) (biotin conjugate) (0.5 mg/ml); Lane 2. MDA5, mAb (1B6) (biotin conjugate) (0.1 mg/ml).
804-878B ELISA
ELISA analysis of the MDA5 protein in cell lysates probed with MDA5, mAb (1B6) (biotin conjugate).
804-878B WB 01
Western blot analysis of the MDA5 protein in cell lysates probed with MDA5, mAb (1B6) (biotin conjugate). Lane 1: Molecular Weight Marker; Lane 2: HeLa Cell Lysate (Prod. No. ADI-LYC-HL100); Lane 3: PC12 Cell Lysate (Prod. No. ADI-LYC-PC100).
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804-878B SDS-PAGE 804-878B ELISA 804-878B WB 01

General Literature References

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses: H. Kato, et al.; Nature 441, 101 (2006), Abstract;
Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties: D.C. Kang, et al.; PNAS 99, 637 (2002), Abstract;

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