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HMGB1 (human) monoclonal antibody (Moby-2)

 
ALX-804-873-C100 100 µg 378.00 USD
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Product Specification

Alternative Name:High mobility group protein B1
 
Clone:Moby-2
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human HMGB1.
 
UniProt ID:P09429
 
Source:Purified from concentrated hybridoma tissue culture supernatant.
 
Species reactivity:Human
 
Applications:ELISA, IP
 
Recommended Dilutions/Conditions:Immunoprecipitation (1:200)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:High mobility group 1 protein (HMGB1) is a chromatin component that is either passively released from necrotic cells or actively secreted in response to angiogenic and inflammatory signals. HMGB1 itself may signal through the receptor for advanced glycation end products (RAGE), and via the Toll-like receptors, TLR2 and TLR4. HMGB1 functions as a late mediator of immune response. Apoptotic cells also release HMGB1 but in an oxidized form that does not trigger the immune response.
 

General Literature References

Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1): J.R. van Beijnum, et al.; Angiogenesis 11, 91 (2008), Abstract;
Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein: H. Kazama, et al.; Immunity 29, 21 (2008), Abstract;
Pattern recognition receptors in the immune response against dying cells: P. Jeannin, et al.; Curr. Opin. Immunol. 20, 530 (2008), Abstract;

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