HMGB1 (human), mAb (Moby-2)



ALX-804-873-C100	100 µg	380.00 USD

Product Specification

Alternative Name:	High mobility group protein B1

Concentration:	1mg/ml

Purity Detail:	Protein G-affinity purified.

Purity:	≥95% (SDS-PAGE)

Formulation:	Liquid. In PBS containing 0.02% sodium azide.

Clone:	Moby-2

Isotype:	Mouse IgG1

Immunogen:	Recombinant human HMGB1.

Source/Host:	Purified from concentrated hybridoma tissue culture supernatant.

Specificity:	Recognizes human HMGB1.

Application:	ELISA Immunoprecipitation (1:200)

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Use/Stability:	Stable for at least 1 year after receipt when stored at -20°C.

Handling:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Miscellaneous/General:	High mobility group 1 protein (HMGB1) is a chromatin component that is either passively released from necrotic cells or actively secreted in response to angiogenic and inflammatory signals. HMGB1 itself may signal through the receptor for advanced glycation end products (RAGE), and via the Toll-like receptors, TLR2 and TLR4. HMGB1 functions as a late mediator of immune response. Apoptotic cells also release HMGB1 but in an oxidized form that does not trigger the immune response.

General Literature References

Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1): J.R. van Beijnum, et al.; Angiogenesis 11, 91 (2008), Abstract;

Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein: H. Kazama, et al.; Immunity 29, 21 (2008), Abstract;

Pattern recognition receptors in the immune response against dying cells: P. Jeannin, et al.; Curr. Opin. Immunol. 20, 530 (2008), Abstract;