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TGF-βRIII (human) monoclonal antibody (Jack-1)

 
ALX-804-871-C100 100 µg 367.00 USD
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Product Specification

Alternative Name:TGFR-3, Transforming growth factor β receptor III, Betaglycan
 
Clone:Jack-1
 
Host:Mouse
 
Isotype:IgG2b
 
Immunogen:Recombinant human TGF-βRIII cytoplasmic domain (aa 809-850).
 
UniProt ID:Q03167
 
Source:Purified from concentrated hybridoma tissue culture supernatant.
 
Species reactivity:Human
 
Applications:IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (1:200)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:TGF-β receptor III (TGF-βRIII; betaglycan) is an ubiquitously expressed transmembrane proteoglycan TGF-β co-receptor that regulates TGF-β signalling by increasing the binding of TGF-β to the subunit II or TGF-β receptor. (Note: The TGF-β receptor III is a co-receptor of TGF-β receptor, composed of subunit I and II; TGF-β receptor III increases the binding of TGF-β to the subunit II. In this way it can regulate the signaling.) TGF-β receptor III expression is lost in many human breast and prostate cancers and correlates with the resistance to the tumor suppressor effects of TGF-β . The overexpression of TGF-β receptor III in breast cancer cells suppresses their tumorigenicity in an animal model.
 

General Literature References

Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta: N. Hempel, et al.; Carcinogenesis 29, 905 (2008), Abstract;
The type III transforming growth factor-beta receptor as a novel tumor suppressor gene in prostate cancer: R.S. Turley, et al.; Cancer Res. 67, 1090 (2007), Abstract; Full Text
The type III TGF-beta receptor suppresses breast cancer progression: M. Dong, et al.; J. Clin. Invest. 117, 206 (2006), Abstract; Full Text

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For Research Use Only. Not for use in diagnostic procedures.
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