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MDA5 (human) monoclonal antibody (Hely-1)

ALX-804-863-C100 100 µg 432.00 USD
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Product Specification

Alternative Name:Helicard, Melanoma differentiation-associated gene 5, Interferon-induced helicase C domain-containing protein 1, RH116, CADM-140 autoantigen, RIG-I-like receptor 2, RLR-2
Immunogen:Recombinant human MDA5 (melanoma differentiation-associated gene 5) (aa 78-555).
UniProt ID:Q9BYX4
Source:Purified from concentrated hybridoma tissue cell culture supernatant.
Species reactivity:Human
Applications:ELISA, IP, WB
Recommended Dilutions/Conditions:Immunoprecipitation (1:100)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:ELISA
Immunoprecipitation (1:100)
Western Blot (1:1'000)
Purity Detail:Protein G-affinity purified.
Formulation:Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:MDA5 and RIG-I are highly conserved helicases involved in the innate immune response to virus. MDA-5 ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. After binding nonself-ligand, RIG-I and MDA5 interact via their CARD domains with the signaling-adaptor molecule, IPS-1 (also known as MAVS, VISA and Cardif), which leads to the induced expression of IFN-β, IRF3-target genes and NF- κB target genes to drive antiviral and inflammatory responses.

General Literature References

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses: H. Kato, et al.; Nature 441, 101 (2006), Abstract;
Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties: D.C. Kang, et al.; PNAS 99, 637 (2002), Abstract;

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