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Omentin 1 (human) monoclonal antibody (Saly-1)

 
ALX-804-850-C100 100 µg 379.00 USD
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Product Specification

Alternative Name:Intelectin-1, Intestinal lactoferrin receptor, Galactofuranose-binding lectin, Endothelial lectin HL-1
 
Clone:Saly-1
 
Host:Mouse
 
Isotype:IgG2b
 
Immunogen:Recombinant human omentin 1 (intelectin-1) (aa 17-231).
 
UniProt ID:Q8WWA0
 
Source:Purified from concentrated hybridoma tissue cell culture supernatant.
 
Species reactivity:Human
 
Applications:ELISA, IHC (PS), WB
 
Recommended Dilutions/Conditions:ELISA (capture)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:Omentin 1 (also named intelectin-1, endothelial lectin HL-1 and intestinal lactoferrin receptor) has been identified as a visceral fat (or omental fat) depot-specific adipokine. Omentin 1 is a secreted protein of ~38 kDa containing a fibrinogen-related domain. Omentin 1 is highly expressed in the omental fat, and much less in intestine, lung and heart. Addition of recombinant omentin in vitro did not affect basal, but enhanced insulin-stimulated glucose uptake in subcutaneous as well as in omental human adipocytes. Omentin 1 triggers AKT signalling in the absence of insulin.
 
804-850 ihc
Figure: Immunohistochemical staining of endogenous human Omentin 1 in different human tissues (paraffin sections) using MAb to Omentin 1 (Saly-1) (Prod. No. ALX-804-850). Method: Different human normal tissues (A: Rectum; B: Small Intestine; C: Stomach) or cancer tissues (D: Colorectal cancer) were stained with MAb to Omentin 1 (Saly-1) by standard immunohistochemistry. Pictures courtesy of Human Protein Atlas (www.proteinatlas.org).
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804-850 ihc

Product Literature References

Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose: B.K. Tan, et al.; Diabetes 57, 801 (2008), Abstract;

General Literature References

Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action: R.Z. Yang, et al.; Am. J. Physiol. Endocrinol. Metab. 290, E1253 (2006), Abstract;

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Omentin 1 polyclonal antibody (AT117) 

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