Omentin 1 (human), mAb (Saly-1)



ALX-804-850-C100	100 µg	349.00 USD

Product Specification

Alternative Name:	Intelectin-1, Intestinal lactoferrin receptor, Galactofuranose-binding lectin, Endothelial lectin HL-1

Concentration:	1mg/ml

Purity Detail:	Protein G-affinity purified.

Purity:	≥95% (SDS-PAGE)

Formulation:	Liquid. In PBS containing 0.02% sodium azide.

Clone:	Saly-1

Isotype:	Mouse IgG2b

Immunogen:	Recombinant human omentin 1 (intelectin-1) (aa 17-231).

Source/Host:	Purified from concentrated hybridoma tissue cell culture supernatant.

Specificity:	Recognizes human omentin 1.

Application:	ELISA (capture) Immunohistochemistry (paraffin sections) Western Blot (1:1'000)

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Use/Stability:	Stable for at least 1 year after receipt when stored at -20°C.

Handling:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Miscellaneous/General:	Omentin 1 (also named intelectin-1, endothelial lectin HL-1 and intestinal lactoferrin receptor) has been identified as a visceral fat (or omental fat) depot-specific adipokine. Omentin 1 is a secreted protein of ~38 kDa containing a fibrinogen-related domain. Omentin 1 is highly expressed in the omental fat, and much less in intestine, lung and heart. Addition of recombinant omentin in vitro did not affect basal, but enhanced insulin-stimulated glucose uptake in subcutaneous as well as in omental human adipocytes. Omentin 1 triggers AKT signalling in the absence of insulin.

Figure: Immunohistochemical staining of endogenous human Omentin 1 in different human tissues (paraffin sections) using MAb to Omentin 1 (Saly-1) (Prod. No. ALX-804-850). Method: Different human normal tissues (A: Rectum; B: Small Intestine; C: Stomach) or cancer tissues (D: Colorectal cancer) were stained with MAb to Omentin 1 (Saly-1) by standard immunohistochemistry. Pictures courtesy of Human Protein Atlas (www.proteinatlas.org).

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Product Literature References

Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose: B.K. Tan, et al.; Diabetes 57, 801 (2008), Abstract;

General Literature References

Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action: R.Z. Yang, et al.; Am. J. Physiol. Endocrinol. Metab. 290, E1253 (2006), Abstract;