Product Specification
| Alternative Name: | A-Proliferation-inducing ligand, TNFSF 13, CD256 |
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| Concentration: | 1mg/ml |
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| Purity: | 95% (SDS-PAGE) |
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| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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| Clone: | Aprily-2 |
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| Isotype: | Mouse IgG1 |
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| Immunogen: | Recombinant human APRIL (aa 93-233). |
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| Source/Host: | Purified from concentrated hybridoma tissue culture supernatant. |
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| Specificity: | Recognizes human APRIL. |
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| Application: | Immunohistochemistry (paraffin sections (1:500)) |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored as recommended. |
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| Handling: | Avoid freeze/thaw cycles. |
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Figure: Biopsy of tumor lesion from a patient with lymphoma (DLBCL) stained with MAb to APRIL (Aprily-2) (
ALX-804-844). The biopsy was stained by standard immunohistochemistry. The figure shows the selective accumulation of APRIL around tumor cells.
Picture courtesy of Dr. Bertrand Huard (University of Geneva).
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Product Literature References
The source of APRIL up-regulation in human solid tumor lesions: P. Mhawech-Fauceglia, et al.; J. Leukoc. Biol.
80, 697 (2006),
Abstract;
General Literature References
BAFF and APRIL: A Tutorial on B Cell Survival: F. Mackay, et al.; Annu. Rev. Immunol. (2002),
Abstract;