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IL-33 monoclonal antibody (Nessy-1) (preservative free)



ALX-804-840PF-C100	100 µg	Preservative Free	356.00 USD
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Replaces Prod. #: ALX-804-840/1PF

Product Specification

Alternative Name:	Interleukin-33, IL-1F11, NF-HEV

Clone:	Nessy-1

Host:	Mouse

Isotype:	IgG1

Immunogen:	Recombinant human IL-33 (aa 112-270) (Prod. No. ALX-522-098).

UniProt ID:	O95760

Gene/Protein Identifier:	90865 (Entrez GeneID), 608678 (OMIM)

Source:	Purified from ascites.

Species reactivity:	Human, Mouse, Rat

Specificity:	Recognizes pro-IL-33 (precursor) and mature IL-33.

Applications:	ELISA, IHC (PS), IP, WB

Recommended Dilutions/Conditions:	Immunoprecipitation (1:100) Western Blot (1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Purity Detail:	Protein G-affinity purified.

Formulation:	Liquid. In PBS.

Use/Stability:	Stable for at least 1 year after receipt when stored at -20°C.

Shipping:	Shipped on Blue Ice

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Figure: Immunohistochemical staining of endogenous human IL-33 in different human tissues (paraffin sections) using MAb to IL-33 (Nessy-1) (Prod. No. ALX-804-840). Method: Different human normal tissues (A: Stomach; B: Bronchus; C: Vulva/Anal skin; D: Nasopharynx) or cancer tissues (E: Colorectal cancer; F: Malignant glioma) were stained with MAb to lL-33 (Nessy-1) by standard immunohistochemistry. Pictures courtesy of Human Protein Atlas (http://www.proteinatlas.org/).

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Product Literature References

Nuclear Interleukin-33 Is Generally Expressed in Resting Endothelium but Rapidly Lost upon Angiogenic or Proinflammatory Activation: A.M. Küchler, et al.; Am. J. Pathol. 173, 1229 (2008), Abstract;

General Literature References

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005), Abstract;

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