Recombinant human IL-33 (aa 112-270) (Prod. No. ALX-522-098).
UniProt ID:
O95760
Gene/Protein Identifier:
90865 (Entrez GeneID), 608678 (OMIM)
Source:
Purified from ascites.
Species reactivity:
Human, Mouse, Rat
Specificity:
Recognizes pro-IL-33 (precursor) and mature IL-33.
Applications:
ELISA, IHC (PS), IP, WB
Recommended Dilutions/Conditions:
Immunoprecipitation (1:100) Western Blot (1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.
Purity Detail:
Protein G-affinity purified.
Formulation:
Liquid. In PBS.
Use/Stability:
Stable for at least 1 year after receipt when stored at -20°C.
Shipping:
Shipped on Blue Ice
Short Term Storage:
+4°C
Long Term Storage:
-20°C
Figure: Immunohistochemical staining of endogenous human IL-33 in different human tissues (paraffin sections) using MAb to IL-33 (Nessy-1) (Prod. No. ALX-804-840). Method: Different human normal tissues (A: Stomach; B: Bronchus; C: Vulva/Anal skin; D: Nasopharynx) or cancer tissues (E: Colorectal cancer; F: Malignant glioma) were stained with MAb to lL-33 (Nessy-1) by standard immunohistochemistry. Pictures courtesy of Human Protein Atlas (http://www.proteinatlas.org/).
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Product Literature References
Nuclear Interleukin-33 Is Generally Expressed in Resting Endothelium but Rapidly Lost upon Angiogenic or Proinflammatory Activation: A.M. Küchler, et al.; Am. J. Pathol. 173, 1229 (2008), Abstract;
General Literature References
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005), Abstract;