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IL-33 monoclonal antibody (Nessy-1)

 
ALX-804-840-C100 100 µg 367.00 USD
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Replaces Prod. #: ALX-804-840/1

Product Specification

Alternative Name:Interleukin-33, IL-1F11, NF-HEV
 
Clone:Nessy-1
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human IL-33 (aa 112-270) (Prod. No. ALX-522-098).
 
UniProt ID:O95760
 
Gene/Protein Identifier:90865 (Entrez GeneID), 608678 (OMIM)
 
Source:Purified from ascites.
 
Species reactivity:Human, Mouse, Rat
 
Specificity:Recognizes pro-IL-33 (precursor) and mature IL-33.
 
Applications:ELISA, IHC (PS), IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (1:100)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
804-8401 new 090216
Figure: Immunohistochemical staining of endogenous human IL-33 in different human tissues (paraffin sections) using MAb to IL-33 (Nessy-1) (Prod. No. ALX-804-840). Method: Different human normal tissues (A: Stomach; B: Bronchus; C: Vulva/Anal skin; D: Nasopharynx) or cancer tissues (E: Colorectal cancer; F: Malignant glioma) were stained with MAb to lL-33 (Nessy-1) by standard immunohistochemistry. Pictures courtesy of Human Protein Atlas (http://www.proteinatlas.org/).
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804-8401 new 090216

Product Literature References

An antitumorigenic role for the IL-33 receptor, ST2L, in colon cancer: C. O'Donnell, et al. ; Br. J. Cancer 114, 37 (2016), Abstract; Full Text
Extracellular IL-33 cytokine, but not endogenous nuclear IL-33, regulates protein expression in endothelial cells: V. Gautier, et al.; Sci. Rep. 6, 34255 (2016), Application(s): Western blot, Abstract; Full Text
Loss of interleukin 33 expression in colonic crypts - a potential marker for disease remission in ulcerative colitis: M.D. Gundersen, et al.; Sci. Rep. 6, 35403 (2016), Application(s): Immunostaining, paraffin-embedded biopsies , Abstract; Full Text
TLR3 Agonist Poly-IC Induces IL-33 and Promotes Myelin Repair: C. Natarajan, et al.; PLoS One 11, e0152163 (2016), Application(s): Western blot, Abstract; Full Text
Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice: H. Chen, et al.; Neuroscience 308, 157 (2015), Application(s): Western Blot, Abstract;
MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease: N. L. Millar, et al.; Nat. Commun. 6, 6774 (2015), Application(s): Immunohistochemistry, Abstract; Full Text
Nuclear IL-33 regulates soluble ST2 receptor and IL-6 expression in primary human arterial endothelial cells and is decreased in idiopathic pulmonary arterial hypertension: D. Shao, et al.; Biochem. Biophys. Res. Commun. 451, 8 (2014), Application(s): Immunohistochemistry using human paraffin-embedded lung tissue sections; Immunoprecipitation and Western blot using human pulmonary arterial endothelial cells (HPAECs) and lung microvascular endothelial cells (HLMVECs), Abstract;
The Experimentally Induced Psoriatic Lesion Associates with Rapid but Transient Decrease in Interleukin-33 Immunostaining in Epidermis: M.M. Suttle, et al.; Acta Derm. Venereol. 95, 536 (2014), Application(s): Immunocytochemistry using human keratinocytes, Abstract; Full Text
Unique Temporal and Spatial Expression Patterns of IL-33 in Ovaries during Ovulation and Estrous Cycle Are Associated with Ovarian Tissue Homeostasis: C.I. Carlock, et al.; J. Immunol. 193, 161 (2014), Application(s): Western blot application, Abstract;
IL-33 is expressed in epithelia from patients with cystic fibrosis and potentiates neutrophil recruitment: L. Roussel, et al.; J. Allergy Clin. Immunol. 131, 913 (2013), Application(s): Immunohistochemistry using human lung tissue samples, Abstract;
Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice: K. Yasuda, et al.; Proc. Natl. Acad. Sci. 109, 3451 (2012), Application(s): Immunoblotting analysis of the levels of IL-33 protein in the lungs from mice, Abstract; Full Text
Interleukin 33 as a Mechanically Responsive Cytokine Secreted by Living Cells: R. Kakkar, et al.; J. Biol. Chem. 287, 6941 (2012), Abstract; Full Text
Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation: J. Louten, et al. ; Int. Immunol. 23, 307 (2011), Application(s): IHC application with murine lung tissue, Abstract; Full Text
IL-33 Exacerbates Acute Kidney Injury: A. Akcay, et al.; J. Am. Soc. Nephrol. 22, 2057 (2011), Application(s): IHC application with Kidney tissues , Abstract; Full Text
Interleukin-33 Induces Expression of Adhesion Molecules and Inflammatory Activation in Human Endothelial Cells and in Human Atherosclerotic Plaques: S. Demyanets, et al.; Arterioscler. Thromb. Vasc. Biol. 31, 2080 (2011), Abstract; Full Text
The Dual Function Cytokine IL-33 Interacts with the Transcription Factor NF-kappaB To Dampen NF-kappaB–Stimulated Gene Transcription: S. Ali, et al.; J. Immunol. 187, 1609 (2011), Abstract; Full Text
The IL1-like cytokine IL33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis: M. Manetti, et al.; Ann. Rheum. Dis. 69, 598 (2010), Abstract;
Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages: T. Ohno, et al.; J. Immunol. 183, 7890 (2009), Abstract; Full Text
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation: M. Kurowska-Stolarska, et al.; J. Immunol. 183, 64649 (2009), Application(s): Immunohistochemistry application with frozen sections of bronchial tissue , Abstract; Full Text
Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells: D. Préfontaine, et al.; J. Immunol. 183, 5094 (2009), Application(s): Immunocytochemistry application with bronchial tissue samples , Abstract; Full Text
Interleukin-33 Is Biologically Active Independently of Caspase-1 Cleavage: D. Talabot-Ayer, et al.; J. Biol. Chem. 284, 19420 (2009), Abstract; Full Text
The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1: C. Cayrol & J.-P. Girard; PNAS 106, 9021 (2009), Abstract; Full Text
Nuclear Interleukin-33 Is Generally Expressed in Resting Endothelium but Rapidly Lost upon Angiogenic or Proinflammatory Activation: A.M. Küchler, et al.; Am. J. Pathol. 173, 1229 (2008), Abstract;

General Literature References

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005), Abstract;

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