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TIRAP (human) monoclonal antibody (Sebi-1)

 
ALX-804-829-C100 100 µg 330.00 USD
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Product Specification

Alternative Name:Toll-interleukin 1 receptor domain-containing adapter protein, MyD88 adapter-like protein, Mal
 
Clone:Sebi-1
 
Host:Rat
 
Isotype:IgG2a
 
Immunogen:Recombinant human TIRAP (Mal) (aa 1-215).
 
UniProt ID:P58753
 
Species reactivity:Human
 
Applications:IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (1:200)
Western Blot (1:500)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading pathogens. Recognition of microbial components by TLRs triggers activation of the innate immune system. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors have been discovered to date, MyD88, Trif (TIR-domain-containing adaptor inducing interferon-β), TIRAP (TIR domain-containing adaptor protein)/Mal (MyD88 adaptor-like), TRAM (Trif-related adaptor molecule) and SARM (SAM and ARM-containing protein). MyD88 is common to all TLR-mediated pathways, which lead to the production of inflammatory cytokines, whereas TRIF mediates induction of IFN-β in TLR3 and TLR4 signalling pathways. TIRAP/Mal is implicated in the TLR2- and TLR4-mediated MyD88-dependent signalling pathway. TRAM is specifically involved in the TLR4-mediated TRIF-dependent pathway. Thus, TIR domain-containing adaptors provide specificity of TLR signalling.
 

General Literature References

Inferences, questions and possibilities in Toll-like receptor signalling: B. Beutler; Nature 430, 257 (2004), Abstract;
TIRAP: an adapter molecule in the Toll signaling pathway: T. Horng, et al.; Nat. Immunol. 2, 835 (2001), Abstract; Full Text

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