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LTβR (human) monoclonal antibody (Carlos-1)

ALX-804-815-C100 100 µg 290.00 USD
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Product Specification

Alternative Name:Lymphotoxin-β receptor, TNFRSF 3, Tumor necrosis factor receptor 2 related protein, Tumor necrosis factor C receptor, Tumor necrosis factor receptor superfamily member 3 [precursor]
Immunogen:Recombinant human LTβR cysteine-rich region (aa 28-220).
UniProt ID:P36941
Source:Purified from concentrated hybridoma tissue culture supernatant.
Species reactivity:Human
Applications:Flow Cytometry, IP
Recommended Dilutions/Conditions:Flow Cytometry (1:1,000)
Immunoprecipitation (1:200)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:The LTβR activates two different NF-κB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes.  LTβR activates the classical NF-κB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1β.  However, LTβR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
Figure: FACS analysis of cells with MAb to LTbR (human) (Carlos-1) (Prod. No. ALX-804-815).Method: HEK 293T cells (5x105) were mock transfected (thin line) or transfected with an expression plasmid enabling surface expression of the extracellular domain of human LTbR  (thick line). Cells were incubated on ice for 30 min. in 50µl FACS buffer (PBS, 5% fetal calf serum, 0.02% azide) containing 1µg/ml of MAb to LTbR (human) (Carlos-1) (Prod. No. ALX-804-815). After washing in FACS buffer, R-PE-conjugated antibody to rat IgG (Prod. No. ALX-211-053) was added. Cells were incubated on ice for 30 min., washed and then analyzed by flow cytometry.
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General Literature References

Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis: J. Kuai, et al.; J. Biol. Chem. 278, 14363 (2003), Abstract; Full Text
Discrete signaling regions in the lymphotoxin-beta receptor for tumor necrosis factor receptor-associated factor binding, subcellular localization, and activation of cell death and NF-kappaB pathways: W.R. Force, et al.; J. Biol. Chem. 275, 11121 (2000), Abstract; Full Text
Tumor necrosis factor receptor and Fas signaling mechanisms: D. Wallach, et al.; Annu. Rev. Immunol. 17, 331 (1999), Abstract;

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