Acidic nuclear phosphoprotein 32A (human), mAb (RJ1)



ALX-804-811-C100	100 µg	330.00 USD

Product Specification

Alternative Name:	HLA-DR associated protein 1, Acidic nuclear phosphoprotein pp32, HLA-DR-associated protein 1, PHAPI, PP2A inhibitor protein 1α, I1αPP2A, LANP, ANP32A

Concentration:	1mg/ml

Purity Detail:	Protein G-affinity purified.

Purity:	>95% (SDS-PAGE)

Formulation:	Liquid. In PBS containing 0.02% sodium azide.

Clone:	RJ1

Isotype:	Mouse IgG1

Immunogen:	Recombinant human acidic nuclear phosphoprotein 32A.

Source/Host:	Purified from concentrated hybridoma tissue culture supernatant.

Specificity:	Recognizes human acidic nuclear phosphoprotein 32A.

Application:	Immunocytochemistry (1:100-1:200; works on endogenous) Immunoprecipitation (works on endogenous) Western Blot (1:4'000; works on endogenous)

Long Term Storage:	-20°C

Handling:	Avoid freeze/thaw cycles.

Product Literature References

Granzyme a induces caspase-independent mitochondrial damage, a required first step for apoptosis: D. Martinvalet, et al.; Immunity 22, 355 (2005), Abstract;

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A: Z. Fan, et al.; Nat. Immunol. 4, 145 (2003), Abstract;

Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor: Z. Fan, et al.; Cell 112, 659 (2003), Abstract;

HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A: Z. Fan, et al.; Mol. Cell. Biol. 22, 2810 (2002), Abstract; Full Text

Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks: P.J. Beresford, et al.; J. Biol. Chem. 276, 43285 (2001), Abstract; Full Text