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Trop-2 (human) monoclonal antibody (MOv16)

ALX-804-650-C100 100 µg Inquire for pricing
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Product Specification

Alternative Name:Tumor-associated calcium signal transducer 2, TACSTD2, GA733-1
Immunogen:Membrane preparation from human ovarian carcinoma containing human Trop-2 (tumor-associated calcium signal transducer 2).
UniProt ID:P09758
Species reactivity:Human
Applications:Flow Cytometry, ICC, IHC (FS), IP, WB
Recommended Dilutions/Conditions:Flow Cytometry (1-10µg/ml)
Immunocytochemistry (1-10µg/ml)
Immunohistochemistry (frozen sections, 1-10µg/ml)
Immunoprecipitation (1-10µg/ml)
Western Blot (non-reducing, 1-10µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Protein G-affinity purified.
Formulation:Liquid. In 10mM sodium phosphate buffer, pH 7.4, containing 150mM sodium chloride.
Use/Stability:Stable for at least 1 year when stored at +4°C.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Long Term Storage:+4°C
Scientific Background:Trop-2 (tumor-associated calcium signal transducer 2) is a 46-48kDa cell surface glycoprotein that acts as a calcium signal transducer. The molecule is expressed at high levels in human throphoblasts and overexpressed on a large variety of human carcinomas (including breast, colon, lung and prostate cancers). As an example, Trop-2 is among the most highly overexpressed genes in primary ovarian serous papillary tumors compared to normal ovarian epithelium and in in colon tumors compared with normal mucosa. Trop-2 is homologous to Trop-1 and both are homologous to serum IGF-II-binding proteins. The specific role of Trop-2 in normal and tumor cells is not fully defined, but accumulating evidence suggests a regulatory role in the growth of carcinoma cells. Furthermore there is data supporting the hypothesis that Trop-2 is involved in tumor invasion and metastasis. Indeed, TROP2 is one of the cancer-related genes that correlates with biological aggressiveness and poor prognosis of colorectal cancer.
Figure: FACS profiles of human cancer cell lines using MAb to Trop-2 (human) (MOv16) (Prod. No. ALX-804-650). Method: Human cancer cell lines of breast (MCF7 and BT474) and ovary (OVCA432) origin were treated for 30 min. at +4°C with MAb to Trop-2 (human) (MOv16) (10µg/ml) or diluent (control), followed by further incubation with anti-mouse Ig FITC.
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Product Literature References

Pr1E11, a novel anti-TROP-2 antibody isolated by adenovirus-based antibody screening, recognizes a unique epitope: M. Ikeda, et al.; Biochem. Biophys. Res. Commun. 458, 877 (2015), Application(s): Surface Plasmon Resonance (SPR) Analysis, Abstract;
Clinical significance of TROP2 expression in colorectal cancer: T. Ohmachi, et al.; Clin. Cancer Res. 12, 3057 (2006), Abstract;
Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy: A.D. Santin, et al.; Int. J. Cancer 112, 14 (2004), Abstract;
In silico data filtering to identify new angiogenesis targets from a large in vitro gene profiling data set: M.E. Gerritsen, et al.; Physiol. Genomics 10, 13 (2002), Abstract;
Effects of different immunolabeling techniques on the detection of small-cell lung cancer cells in bone marrow: G. Pelosi, et al.; J. Histochem. Cytochem. 47, 1075 (1999), Abstract; Full Text
Human Trop-2 is a tumor-associated calcium signal transducer: E. Ripani, et al.; Int. J. Cancer 76, 671 (1998), Abstract;
Transformation of human keratinocytes is characterized by quantitative and qualitative alterations of the T-16 antigen (Trop-2, MOv-16): M.P. Schon and C.E. Orfanos; Int. J. Cancer 60, 88 (1995), Abstract;
Biochemical characterization of Trop-2, a cell surface molecule expressed by human carcinomas: formal proof that the monoclonal antibodies T16 and MOv-16 recognize Trop-2: S. Alberti, et al.; Hybridoma 11, 539 (1992), Abstract;
Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificity: S. Miotti, et al.; Int. J. Cancer 39, 297 (1987), Abstract;
Human trophoblast cell-surface antigens defined by monoclonal antibodies: M. Lipinski, et al.; PNAS 78, 5147 (1981), Abstract;

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