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c-Myc (human) monoclonal antibody (6A10)

 
ALX-804-632-L001 1 ml 190.00 USD
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Product Specification

Alternative Name:Myc proto-oncogene, Transcription factor p64
 
Clone:6A10
 
Host:Rat
 
Isotype:IgG2a
 
Immunogen:Human c-Myc (aa 1-262).
 
UniProt ID:P01106
 
Species reactivity:Human
 
Applications:ICC, IP, WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (1:10)
Immunoprecipitation (1:10)
Western Blot (1:50)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Liquid. Tissue culture supernatant (TCS) containing 0.1% sodium azide.
 
Use/Stability:Stable for at least 1 year when stored at +4°C.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Scientific Background:Myc proteins are important regulators of cell behaviour and work as transcription factors that belong to the basic region/helix-loop-helix/leucine zipper family of DNA binding proteins. To regulate its target genes, Myc recruits several different cofactors (e.g. PARP-10). They control a variety of cellular functions including protein synthesis, cell cycle progression, and apoptosis, thereby modulating cell growth and proliferation, differentiation, and survivial of cells. The family of myc genes includes B-myc, L-myc, N-myc and s-myc; however only c-myc, L-myc and N-myc have neoplastic potential. The c-Myc gene was discovered as the cellular homolog of the retroviral v-myc oncogene. It is a proto-oncogene, whereas the deregulated expression of c-Myc is observed in the majority of human and animal tumors often with poor prognosis. The proto-oncogene c-Myc is implicated in various physiological processes; cell growth, proliferation, loss of differentiation and cell death (apoptosis). It also has been implicated in the loss and dysfunction of insulin-producing beta cells in diabetes. Studies in mice suggest that c-Myc has unexpected functions during both self-renewal and the differentiation of stem and early progenitor cells. c-Myc activity is normally tightly controlled by external signals including growth factors, mitogens and β-catenin which promote, and factors as TGF-beta which inhibit.
 

Product Literature References

PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation: M. Yu, et al.; Oncogene 24, 1982 (2005), Abstract;
Inhibition of proliferation and apoptosis by the transcriptional repressor Mad1. Repression of Fas-induced caspase-8 activation: S. Gehring, et al.; J. Biol. Chem. 275, 10413 (2000), Abstract; Full Text
Identification and characterization of specific DNA-binding complexes containing members of the Myc/Max/Mad network of transcriptional regulators: A. Sommer, et al.; J. Biol. Chem. 273, 6632 (1998), Abstract; Full Text

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