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Laminin receptor (67kDa) (human) monoclonal antibody (MLuC5)

ALX-804-623-C050 50 µg 215.00 USD
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Product Specification

Alternative Name:67-kDa laminin receptor, 67LR, Laminin receptor 1, Colon carcinoma laminin-binding protein, 40S ribosomal protein SA, p40, 37LRP, RPSA
Immunogen:Extracellular part of recombinant human of 67kDa laminin receptor (laminin receptor 1; 67LR) (monomeric).
UniProt ID:P08865
Species reactivity:Human
Specificity:Recognizes the extracellular part of the 67kDa laminin receptor.
Applications:Flow Cytometry, ICC, IHC (FS), IHC (PS), FUNC
Application Notes:Functional Application: Partially inhibits the binding of soluble laminin.
Formulation:Liquid. In 20mM TRIS, pH 7.4, containing 150mM sodium chloride and 0.02% sodium azide.
Handling:Do not freeze.
Shipping:Shipped on Blue Ice
Long Term Storage:+4°C
Scientific Background:The interactions between tumor cells and laminin or other components of the extracellular matrix have been shown to play an important role in tumor invasion and metastasis. They are mediated by different cell surface molecules such as the 67kD laminin receptor (67LR; laminin receptor 1), a protein derived from a smaller precursor, the 37LRP. In addition to its role as laminin receptor, 67LR also acts as a receptor for viruses and is involved with internalization of the prion protein.

Product Literature References

The p67 laminin receptor identifies human erythroid progenitor and precursor cells and is functionally important for their bone marrow lodgment: H. Bonig, et al.; Blood 108, 1230 (2006), Abstract;
67-kDa laminin receptor promotes internalization of cytotoxic necrotizing factor 1-expressing Escherichia coli K1 into human brain microvascular endothelial cells: K.J. Kim, et al.; J. Biol. Chem. 280, 1360 (2005), Abstract; Full Text
Identification of genes up-regulated in urothelial tumors: the 67-kd laminin receptor and tumor-associated trypsin inhibitor: C.P. Diggle, et al.; Am. J. Pathol. 163, 493 (2003), Abstract;
Diverse patterns of expression of the 67-kD laminin receptor in human small intestinal mucosa: potential binding sites for prion proteins?: A.N. Shmakov, et al.; J. Pathol. 191, 318 (2000), Abstract;
Laminin mediates tethering and spreading of colon cancer cells in physiological shear flow: J. Kitayama, et al.; Br. J. Cancer 80, 1927 (1999), Abstract;
Laminin receptor in lymph node negative breast carcinoma: M. Nadji, et al.; Cancer 85, 432 (1999), Abstract;
The nonintegrin laminin binding protein (p67 LBP) is expressed on a subset of activated human T lymphocytes and, together with the integrin very late activation antigen-6, mediates avid cellular adherence to laminin: S.M. Canfield and A.Y. Khakoo; J. Immunol. 163, 3430 (1999), Abstract;
Prognostic significance of 67-kDa laminin receptor expression in advanced gastric cancer: G. de Manzoni, et al.; Oncology 55, 456 (1998), Abstract;
67-Kilodalton laminin receptor expression correlates with worse prognostic indicators in non-small cell lung carcinomas: G. Fontanini, et al.; Clin. Cancer Res. 3, 227 (1997), Abstract;
Expression of the 67 KD laminin receptor in human cervical preneoplastic and neoplastic squamous epithelial lesions: an immunohistochemical study: W. Al-Saleh, et al.; J. Pathol. 181, 287 (1997), Abstract;
High-affinity monomeric 67-kD laminin receptors and prognosis in pancreatic endocrine tumours: G. Pelosi, et al.; J. Pathol. 183, 62 (1997), Abstract;
The spectrum of 67-kD laminin receptor expression in breast carcinoma progression: P. Viacava, et al.; J. Pathol. 182, 36 (1997), Abstract;
Expression of the 67 kD laminin receptor in human ovarian carcinomas as defined by a monoclonal antibody, MLuC5: F.A. van den Brule, et al.; Eur. J. Cancer 32A, 1598 (1996), Abstract;
Expression of the Mr 67,000 laminin receptor is an adverse prognostic indicator in human thyroid cancer: an immunohistochemical study: F. Basolo, et al.; Clin. Cancer Res. 2, 1777 (1996), Abstract;
Immunohistochemical evaluation of multiple biological markers in ductal carcinoma in situ of the breast: T. Perin, et al.; Eur. J. Cancer 32A, 1148 (1996), Abstract;
Killing of laminin receptor-positive human lung cancers by tumor infiltrating lymphocytes bearing gammadelta(+) t-cell receptors: M. Ferrarini, et al.; J. Natl. Cancer Inst. 88, 436 (1996), Abstract;
Overexpression of the 67-kD laminin receptor correlates with tumour progression in human colorectal carcinoma: X. Sanjuan, et al.; J. Pathol. 179, 376 (1996), Abstract;
Expression of the monomeric 67-kd laminin-binding protein in human lymphomas as defined by MLuC5 monoclonal antibody and paraffin section immunohistochemistry: A. Carbone, et al.; Hum. Pathol. 26, 541 (1995), Abstract;
Characterization of two monoclonal antibodies directed against the 67 kDa high affinity laminin receptor and application for the study of breast carcinoma progression: S. Martignone, et al.; Clin. Exp. Metastasis 10, 379 (1992), Abstract;

General Literature References

The 67 kDa laminin receptor: structure, function and role in disease: J. Nelson, et al.; Biosci. Rep. 28, 33 (2008), Abstract; Full Text

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