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Fibulin-1 (human) monoclonal antibody (MEM-2)

ALX-804-622-C050 50 µg Inquire for pricing
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Product Specification

Alternative Name:Basement-membrane protein 90, BM-90, FBLN1
Immunogen:Recombinant human fibulin-1.
UniProt ID:P23142
Species reactivity:Human
Applications:Flow Cytometry, IHC (FS), IHC (PS), IP, WB, FUNC
Application Notes:Functional Application: Blocking.
Formulation:Liquid. In 20mM TRIS, pH 7.4, containing 1.25M sodium chloride and 0.02% sodium azide.
Handling:Do not freeze.
Shipping:Shipped on Blue Ice
Long Term Storage:+4°C
Scientific Background:The fibulins are a family of secreted glycoproteins that are components of elastic matrix fibers and basement membranes. Fibulin-1 is an extracellular matrix protein, which can adhere to endothelial cells and regulate their motility and proliferation. Fibulin-1 is overexpressed in estrogen receptor (ER)-positive ovarian carcinomas and several studies suggest a possible role for fibulin-1 as a tumor suppressor. Xie et al. described that fibulin-1 inhibits tumor growth in HT1080 cell lines by suppressing tumor angiogenesis and inducing apoptosis.

Product Literature References

Fibulin-1 is increased in asthma--a novel mediator of airway remodeling?: J.Y. Lau, et al.; PLoS One 5, e13360 (2010), Abstract; Full Text
Downregulation of several fibulin genes in prostate cancer: A. Wlazlinski, et al.; Prostate 67, 1770 (2007), Abstract;
Regulation of breast cancer response to chemotherapy by fibulin-1: S.M. Pupa, et al.; Cancer Res. 67, 4271 (2007), Abstract;
Immunological and pathobiological roles of fibulin-1 in breast cancer: S.M. Pupa, et al.; Oncogene 23, 2153 (2004), Abstract;
Monoclonal antibody to fibulin-1 generated by genetic immunization: S.M. Pupa, et al.; J. Cell. Biochem. 89, 647 (2003), Abstract;

General Literature References

Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth: L. Xie, et al.; Exp. Biol. Med. (Maywood) 233, 155 (2008), Abstract;

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