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c-erbB-2 (human) monoclonal antibody (MGR2)

ALX-804-573-C100 100 µg Inquire for pricing
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Product Specification

Alternative Name:ErbB2, HER-2, neu, CD340
Immunogen:CaLu 3 lung carcinoma cell line.
UniProt ID:P04626
Species reactivity:Human
Specificity:Recognizes an epitope present in the extracellular domain of c-erbB-2 (HER-2; neu).
Applications:Flow Cytometry, IHC (FS), IP
Application Notes:Immunoprecipitation: Detects a band of ~185kDa.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In 150mM sodium chloride, pH 7.4, containing 0.02% sodium azide.
Handling:Do not freeze.
Shipping:Shipped on Blue Ice
Long Term Storage:+4°C
Scientific Background:The epidermal growth factor type II receptor, c-erbB2 (HER-2; neu), is a transmembrane tyrosine kinase receptor known to play an important role in coordinating the complex ErbB signalling network and to be involved in the development of breast cancer. When c-erbB-2 is overexpressed at high levels, ligand-independent activation of the c-erbB-2 receptor results in an increased mitogen-activated protein kinase and PI(3)K cell signalling, leading to increased cell proliferation. Overexpression of c-erbB-2 has been associated with resistance to chemotherapy and poor survival in several human tumors.

Product Literature References

Analysis of receptor tyrosine kinases (RTKs) and downstream pathways in chordomas: E. Tamborini, et al.; Neuro. Oncol. 12, 776 (2010), Abstract;
Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab: A. Magnifico, et al.; Clin. Cancer Res. 15, 2010 (2009), Abstract;
Inhibition of mammary carcinoma development in HER-2/neu transgenic mice through induction of autoimmunity by xenogeneic DNA vaccination: S.M. Pupa, et al.; Cancer Res. 65, 1071 (2005), Abstract;
Antigenic and immunogenic mimicry of the HER2/neu oncoprotein by phage-displayed peptides: R. Orlandi, et al.; Eur. J. Immunol. 24, 2868 (1994), Abstract;
p185 HER2/neu epitope mapping with murine monoclonal antibodies: F. Centis, et al.; Hybridoma 11, 267 (1992), Abstract;
Selection of monoclonal antibodies which induce internalization and phosphorylation of p185HER2 and growth inhibition of cells with HER2/NEU gene amplification: E. Tagliabue, et al.; Int. J. Cancer 47, 933 (1991), Abstract;

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