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Caspase-12 (mouse) monoclonal antibody (12G6)

ALX-804-511-C100 100 µg 230.00 USD
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Product Specification

Immunogen:p20 fragment of mouse caspase-12 and synthetic peptide corresponding to aa 183-205 (N183KKFDYLFDRDNADTDILNMQEL205) of mouse caspase-12.
UniProt ID:O08736
Species reactivity:Mouse
Specificity:Recognizes an epitope within the p20 fragment of caspase-12.
Crossreactivity:Does not cross-react with mouse caspase-1 or -11.
Applications:ELISA, Flow Cytometry, WB
Application Notes:Detects a band of ~51kDa by Western blot.
Formulation:Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:Caspase-12 is a member of the ICE/CED-3 family of caspases and is detected as a protein of ~51kDa. Overexpression of caspase-12 in cells induces apoptosis. Capase-12 is localised to the endoplasmatic reticulum (ER) and activated by ER stress and specifically cleaves and activates pro-caspase-9 and is also thought to be involved in the apoptosis induced by viral infection. Caspase-12-deficient mice are resistant to ER stress-induced apoptosis. Caspase-12 is probably expressed in many and perhaps all mouse tissues; and is expressed at high levels in skeletal muscle, heart, lung and kidney, and at moderate levels in brain and liver. In many humans caspase-12 is a pseudo gene and not expressed.
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Figure: Detection of overexpressed caspase-12 in 293T cells transiently transfected with a FLAG tagged inactive cysteine mutant of mouse caspase-12 as a band of ~51 kDa by Western blot using MAbs to caspase-12 (clones 11F10 and 12G6) (Prod. No. ALX-804-509 and ALX-804-511).
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Figure: Detection of pro-caspase-12 in MEFs from mice by Western blot using MAbs to caspase-12 (clones 11F10 and 12G6) (Prod. No. ALX-804-509 and ALX-804-511). 
Figure: Detection of endogenous caspase-12 in mouse lung, liver, spleen and pancreas by Western blot using MAb to caspase-12 (12G6) (Prod. No. ALX-804-511) as a band of ~51kDa.  
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