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IL-13 receptor (human) monoclonal antibody (GM-1C8)

 
ALX-804-506-C100 100 µg 334.00 USD
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Product Specification

Alternative Name:IL-13R, CD213, Interleukin-13 receptor
 
Clone:GM-1C8
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Vector containing the cDNA of the extracellular domain of human IL-13Rα1 (interleukin-13 receptor α1 chain).
 
UniProt ID:P78552 (subunit α1), Q14627 (subunit α2)
 
Source:Purified by affinity chromatography from cell culture supernatant.
 
Species reactivity:Human
 
Applications:Flow Cytometry
 
Quality Control:Routinely tested by flow cytometry on BOSC cells transiently transfected with a IL-13Rα1 expression vector.
 
Formulation:Liquid. Antibody in PBS, pH 7.2, containing 0.01% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:IL-13 is an immunoregulatory cytokine secreted predominantly by activated TH2 cells, as well as mast cells and basophils, and is a key mediator in the pathogenesis of allergic inflammation. The human IL-13 receptor (IL-13R) is a heterodimer composed of the interleukin-4 receptor a chain (IL-4Rα) and an IL-13 binding protein, IL-13Rα1.A second IL-13 binding protein, IL-13Rα2, has also been identified, which is believed to act as a "decoy" receptor. IL-13 receptors are expressed on human B cells, basophils, eosinophils, mast cells, endothelial cells, fibroblasts, monocytes, macrophages, respiratory epithelial cells, and smooth muscle cells. However, functional IL-13 receptors have not been demonstrated on human or mouse T cells.

As with other cytokine receptors, the cytoplasmic tails of IL-4 and IL-13 receptor subunits associate with tyrosine kinases of the Janus family (JAK 1
 
804-506
Figure: Specificity testing of GM-1C8. BOSC cells were transiently transfected with an expression vector for the extracellular domain of IL-13Ra1 as well as an irrelevant protein. Expression of the constructs was tested with an anti-tag monoclonal antibody (B, open curves), an irrelevant monoclonal antibody served as negative control (filled curves). For specificity testing (A), GM-1C8 hybridoma supernatant was tested on both the IL-13Ra1 and the irrelevant protein transfectants. A positive signal was obtained only with IL-13Ra1-transfected cells.
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804-506

Product Literature References

Blockade of interleukin-13-mediated cell activation by a novel inhibitory antibody to human IL-13 receptor 1: S. Krause, et al.; Mol. Immunol. 43, 1799 (2006), Abstract;

General Literature References

IL-13 receptors and signaling pathways: an evolving web: G.K. Hershey; J. Allergy Clin. Immunol. 111, 677 (2003), (Review), Abstract;
Interleukin-4 and interleukin-13 signaling connections maps: A.E. Kelly-Welch, et al.; Science 300, 1527 (2003), Abstract;
Structure, binding, and antagonists in the IL-4/IL-13 receptor system: T.D. Mueller, et al.; Biochim. Biophys. Acta 1592, 237 (2002), (Review), Abstract;
IL-4/IL-13 signaling beyond JAK/STAT: H. Jiang, et al.; J. Allergy Clin. Immunol. 105, 1063 (2000), (Review), Abstract;
Differential responses of human monocytes and macrophages to IL-4 and IL-13: P.H. Hart, et al.; J. Leukoc. Biol. 66, 575 (1999), (Review), Abstract;
Interleukin-4 and interleukin-13: their similarities and discrepancies: P. Chomarat and J. Banchereau; Int. Rev. Immunol. 17, 1 (1998), (Review), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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