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Caspase-11 (mouse) monoclonal antibody (8A5)

 
ALX-804-494-C100 100 µg 367.00 USD
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Product Specification

Clone:8A5
 
Host:Rat
 
Isotype:IgG1
 
Immunogen:p20 fragment of mouse caspase-11.
 
UniProt ID:P70343
 
Species reactivity:Mouse, Rat
 
Specificity:The epitope is in the p20 fragment.
 
Applications:Flow Cytometry, WB
 
Application Notes:Detects two bands of ~38kDa and ~43kDa by Western blot.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7. Human caspase-4, thought to be the homolog of mouse caspase-11, may be an effective therapeutic target for treatment of septic shock.
 
804-494 c
Figure: MAb 8A5 detects endogenous caspase-11 in mouse spleen and lymph node as two bands of 43 and 38 kDa. After 16 hrs co-culture with LPS 20 mg/mL elevated levels of caspase-11 are detected in mouse spleen and lymph node.
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804-494 c

General Literature References

Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1: R. Schauvliege, et al.; J. Biol. Chem. 277, 41624 (2002), Abstract; Full Text
Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response: S.J. Kang, et al.; Cell Death Differ. 9, 1115 (2002), Abstract;
Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway: J. Hur, et al.; FEBS Lett. 507, 157 (2001), Abstract;

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