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Folate receptor α monoclonal antibody (Mov18)

 
ALX-804-439-R100 100 µl Inquire for pricing
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Product Specification

Alternative Name:Folate-binding protein, gp38, FRα, FOLR1
 
Clone:Mov18
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Membrane preparation from a human ovarian carcinoma specimen.
 
UniProt ID:P15328
 
Species reactivity:Human
Monkey
 
Specificity:Recognizes membrane-bound and soluble folate receptor (FR) α.
 
Crossreactivity:Does not cross-react with mouse or rat folate receptor. Does not cross-react with the β-isoform.
 
Applications:Flow Cytometry, ICC, IHC (FS), IP, WB
 
Recommended Dilutions/Conditions:Western Blot (avoid reducing reagents; use 0.1% SDS in transferring buffer). Suggested starting dilution for all applications is 1-10µg/ml
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Not recommended for IHC (PS).
 
Purity Detail:Purified from concentrated hybridoma cell culture supernatant.
 
Formulation:Liquid. In PBS, pH 7.4. Contains no preservatives.
 
Use/Stability:Stable for at least one year when stored undiluted at +4°C.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Scientific Background:The folate receptor is a highly selective tumor marker overexpressed in greater than 90% of ovarian carcinomas.
 
804-439n
Figures: Immunoperoxidase staining of acetone-fixed cryostatic sections from a human serous ovary carcinoma at low (A) and high (B) magnification showing membrane localization.
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804-439n

Product Literature References

Folic acid-capped PEGylated magnetic nanoparticles enter cancer cells mostly via clathrin-dependent endocytosis: E. Allard-Vannier, et al.; Biochim. Biophys. Acta 1861, 1578 (2017), Abstract;
Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha: M. F. Hansen, et al.; Cell Signal. 27, 1356 (2015), Application(s): Cell Culture, Western Blot, Abstract;
Expression of folate transporters in human placenta and implications for homocysteine metabolism: N. Solanky, et al.; Placenta 31, 134 (2010), Abstract;
Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism: R. Steinfeld, et al.; Am. J. Hum. Genet. 85, 354 (2009), Abstract;
Functional folate receptor alpha is elevated in the blood of ovarian cancer patients: E. Basal, et al.; PLOS ONE 4, e6292 (2009), Abstract; Full Text
Targeting of porous hybrid silica nanoparticles to cancer cells: J.M. Rosenholm, et al.; ACS Nano 3, 197 (2009), Abstract;
Immunological profiling of a panel of human ovarian cancer cell lines: T.M. Carr, et al.; Cancer Immunol. Immunother. 57, 31 (2008), Abstract;
Molecular requirements for attachment of the glycosylphosphatidylinositol anchor to the human alpha folate receptor: A. Tomassetti, et al.; J. Cell Biochem. 72, 111 (1999), Abstract;
Role of folate receptor and reduced folate carrier in the transport of 5-methyltetrahydrofolic acid in human ovarian carcinoma cells: G. Corona, et al.; Int. J. Cancer 75, 125 (1998), Abstract;
Folate binding protein distribution in normal tissues and biological fluids from ovarian carcinoma patients as detected by the monoclonal antibodies MOv18 and MOv19: L.T. Mantovani, et al.; Eur. J. Cancer 30A, 363 (1994), Abstract;
Effect of hydrostatic pressure and cholesterol depletion on the expression of a tumor-associated antigen: N. Gesmundo, et al.; Eur. J. Biochem. 217, 337 (1993), Abstract;
Isolation and biochemical characterization of the soluble and membrane forms of folate binding protein expressed in the ovarian carcinoma cell line IGROV1: A. Tomassetti, et al.; FEBS Lett. 317, 143 (1993), Abstract;
Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues: S.D. Weitman, et al.; Cancer Res. 52, 3396 (1992), Abstract;
Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein: L.R. Coney, et al.; Cancer Res. 51, 6125 (1991), Abstract;
Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificity: S. Miotti, et al.; Int. J. Cancer 39, 297 (1987), Abstract;

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