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Aryl hydrocarbon receptor monoclonal antibody (RPT1)

 
ALX-804-421-R100 100 µl 604.00 USD
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Product Specification

Alternative Name:AhR
 
Clone:RPT1
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Synthetic peptide corresponding to aa 12-17 (R12KRRKP17) and aa 22-31 (V22KPIPAEGIK31) of mouse AhR (aryl hydrocarbon receptor).
 
UniProt ID:P30561
 
Species reactivity:Human, Mouse, Rat
 
Applications:IF, IHC (PS), IP, WB
 
Recommended Dilutions/Conditions:Immunofluorescence (1:100-1:1,000)
Immunohistochemistry (paraffin sections, 1:10-1:100)
Western Blot (1:1500-1:2,000). Suggested dilutions/conditions may not be available for all applications. Optimal should be determined individually for each application.
 
Application Notes:Detects a band of ~95kDa by Western blot.
 
Formulation:Liquid. Ascites containing 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The aryl hydrocarbon receptor (AhR), also known as the dioxin receptor, is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AhR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the Ah Receptor.
Studies indicate that in non-ligand activated cells, AhR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AhR is believed to transform to a nuclear, DNA binding form. This transformation process appears to involve dissociation of HSP90 from AhR followed by formation of a heterodimer with AhR nuclear translocator protein (Arnt). The AhR-ligand complex appears to initiate gene transcription of cytochrome P450 1A1.
 

Product Literature References

Subunit composition of the heteromeric cytosolic aryl hydrocarbon receptor complex: H.S. Chen & G.H. Perdew; J. Biol. Chem. 269, 27554 (1994), Abstract; Full Text

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Flow Cytometry, ICC, IF, IHC (FS), IP, WB, ChIP, Gel Shift | Print as PDF
 
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