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Toll-like receptor 4 (human) monoclonal antibody (HTA125) (FITC conjugate)

ALX-804-419F-T100 100 tests FITC 321.00 USD
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Product Specification

Alternative Name:TLR4, CD284
Immunogen:Ba/F3 cell line expressing human TLR4 (Toll-like receptor 4).
UniProt ID:O00206
Species reactivity:Human
Applications:Flow Cytometry, IP
Application Notes:Not suitable for Western blot (does not detect denatured protein).
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Use/Stability:Stable for at least 1 year after receipt when stored as recommended.
Handling:Do not freeze. Protect from light.
Shipping:Blue Ice Not Frozen
Short Term Storage:+4°C
Long Term Storage:+4°C
Technical Info/Product Notes:Replacement for ADI-CSA-800FI

Product Literature References

Lipopolysaccharides Belonging to Different Salmonella Serovars Are Differentially Capable of Activating Toll-Like Receptor 4: Chessa D., et al.; Infect. Immun. 82, 4553 (2014), Application(s): IHC on formalin-fixed, paraffin-embedded ovine and human placenta tissue sections, Abstract; Full Text
A Single Nucleotide Polymorphism in 3'-Untranslated Region Contributes to the Regulation of Toll-like Receptor 4 Translation: Sato K., et al.; J. Biol. Chem. 287, 25163 (2012), Application(s): Flow cytometry analysis of human peripheral blood monocytes (PBMCs), Abstract; Full Text
TAK1 contributes to the enhanced responsiveness of LTB4-treated neutrophils to Toll-like receptor ligands: Gaudreault E., et al.; Int. Immunol. 24, 693 (2012), Application(s): Flow cytometry analysis of human neutrophils, Abstract; Full Text
Interactions between TLR2, TLR4, and mannose receptors with gp43 from Paracoccidioides brasiliensis induce cytokine production by human monocytes: Nakaira-Takahagi E., et al.; Med. Mycol. 49, 694 (2011), Abstract;
Helicobacter pylori Augments Growth of Gastric Cancers via the Lipopolysaccharide-Toll-like Receptor 4 Pathway whereas Its Lipopolysaccharide Attenuates Antitumor Activities of Human Mononuclear Cells: Chochi K., et al.; Clin. Cancer Res. 14, 2909 (2008), Application(s): Flow cytometry analysis of human gastric cancer cell lines MKN28, MKN45, NUGC3, and KATOIII, Abstract; Full Text
The Extra Domain A from Fibronectin Targets Antigens to TLR4-Expressing Cells and Induces Cytotoxic T Cell Responses In Vivo: Lasarte J. J., et al.; J. Immunol. 178, 748 (2007), Application(s): Flow cytometry analysis of human HEK293 cells, Abstract; Full Text
Escherichia coli Strain Nissle 1917 Ameliorates Experimental Colitis via Toll-Like Receptor 2- and Toll-Like Receptor 4-Dependent Pathways: Grabig A., et al.; Infect. Immun. 74, 4075 (2006), Application(s): Flow cytometry analysis of human peripheral blood T-cells (PBTs), Abstract; Full Text
Activation of Acid Sphingomyelinase and Its Inhibition by the Nitric Oxide/Cyclic Guanosine 3',5'-Monophosphate Pathway: Key Events in Escherichia coli-Elicited Apoptosis of Dendritic Cells: Falcone S., et al.; J. Immunol. 173, 4452 (2004), Application(s): Flow cytometry analysis of human dendritic cells, Abstract; Full Text
Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14: E. Ellingsen, et al.; Med. Sci. Monitor 8, BR149 (2002), Abstract; Full Text
Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction: E. Latz, et al.; J. Biol. Chem. 277, 47834 (2002), Abstract; Full Text
Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation: Triantafilou M., et al.; J. Cell Sci. 115, 2603 (2002), Application(s): Energy transfer (FRET) measurements between TLR4 and GM-1 ganglioside before and after LPS stimulation., Abstract; Full Text
Lipopolysaccharide induces physical proximity between CD14 and toll-like receptor 4 (TLR4) prior to nuclear translocation of NF-κB: Q. Jiang, et al.; J. Immunol. 165, 3541 (2000), Abstract; Full Text
Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor 4-MD-2: S. Akashi, et al.; BBRC 268, 172 (2000), Abstract;
Toll-like receptors confer responsiveness to lipopolysaccharide from Porphyromonas gingivalis in human gingival fibroblasts: K. Tabeta, et al.; Infect. Immun. 68, 3731 (2000), Abstract; Full Text
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4: R. Shimazu, et al.; J. Exp. Med. 189, 1777 (1999), Abstract; Full Text

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