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Toll-like receptor 4 (human) monoclonal antibody (HTA125)

 
ALX-804-419-C100 100 µg 287.00 USD
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Product Specification

Alternative Name:TLR4, CD284
 
Clone:HTA125
 
Host:Mouse
 
Isotype:IgG2a
 
Immunogen:Ba/F3 cell line expressing human TLR4 (Toll-like receptor 4).
 
UniProt ID:O00206
 
Species reactivity:Human
 
Applications:Flow Cytometry, IP
 
Recommended Dilutions/Conditions:Flow Cytometry (1:10-1:100; incubate at +37°C and then on ice with GAM-FITC)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Use preservative free formulation for Functional Application.
Not suitable for Western blot (does not detect denatured protein).
 
Formulation:Liquid. In PBS containing 0.02% sodium azide
 
Use/Stability:Stable for at least 1 year after receipt when stored as recommended.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Technical Info/Product Notes:Replacement for ADI-CSA-800, see also ADI-CSA-800FI
 

Product Literature References

Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis: G. Bhattarai, et al.; Acta Biomater. 29, 398 (2016), Application(s): Western Blot, Abstract;
Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14: E. Ellingsen, et al.; Med. Sci. Monitor 8, BR149 (2002), Abstract; Full Text
Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction: E. Latz, et al.; J. Biol. Chem. 277, 47834 (2002), Abstract; Full Text
Lipopolysaccharide induces physical proximity between CD14 and toll-like receptor 4 (TLR4) prior to nuclear translocation of NF-κB: Q. Jiang, et al.; J. Immunol. 165, 3541 (2000), Abstract; Full Text
Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor 4-MD-2: S. Akashi, et al.; BBRC 268, 172 (2000), Abstract;
Toll-like receptors confer responsiveness to lipopolysaccharide from Porphyromonas gingivalis in human gingival fibroblasts: K. Tabeta, et al.; Infect. Immun. 68, 3731 (2000), Abstract; Full Text
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4: R. Shimazu, et al.; J. Exp. Med. 189, 1777 (1999), Abstract; Full Text

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